{"id":1482,"date":"2021-01-14T01:36:14","date_gmt":"2021-01-13T17:36:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1482"},"modified":"2021-01-14T01:36:14","modified_gmt":"2021-01-13T17:36:14","slug":"the-important-role-of-2075-45-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1482","title":{"rendered":"The important role of 2075-45-8"},"content":{"rendered":"

Application of 2075-45-8<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2075-45-8 as follows.<\/p>\n

4-Bromo-lH-pyrazole (3674 mg, 25 mmol, 1.0 eq),CuI (95 mg, 0.5 mmol, 0.02 eq) and K2CO3 (7256 mg, 52.5 mmol, 2.1 eq) were added to a dry pressure tube equipped with a magnetic stirring bar. (570 mg, 5 mmol, 0.2 eq), 1-iodo-3-methoxybenzene (3.57 mL, 30 mmol, 1.2 eq) and solvent dioxane ) Was added in a nitrogen-filled glove box. The mixture was bubbled with nitrogen for 5 minutes. The tube was sealed prior to removal from the glove box.The mixture was stirred in an oil bath100At temperatureAnd stirred for 2 days.The mixture was then cooled to room temperature, filtered and washed with ethyl acetate. The filtrate was concentrated and the residue was purified by column chromatographyPurification via column chromatography on silica gel using ethyl acetate (20: 1-15: 1) gave 4.09 g of the desired product 4-bromo-1- (3-methoxyphenyl) Pyrazole 3 in 65% yield.<\/p>\n

According to the analysis of related databases, 2075-45-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 2075-45-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[248,131],"tags":[126],"class_list":["post-1482","post","type-post","status-publish","format-standard","hentry","category-2075-45-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 2075-45-8<\/title>\n<meta name=\"description\" content=\"Application of 2075-45-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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