{"id":1478,"date":"2021-01-14T01:36:14","date_gmt":"2021-01-13T17:36:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1478"},"modified":"2021-01-14T01:36:14","modified_gmt":"2021-01-13T17:36:14","slug":"some-tips-on-287922-71-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1478","title":{"rendered":"Some tips on 287922-71-8"},"content":{"rendered":"

Application of 287922-71-8<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 287922-71-8, name is 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

A mixture of 4-bromo-1-methyl-1H-pyrazole-3-carbonitrile (29-b) (60.8 mg, 0.327 mmol) , 4, 4, 4′, 4′, 5, 5, 5′, 5′-octamethyl-2, 2′-bi (1, 3, 2-dioxaborolane) (29-c) (91.0 mg, 0.360 mmol) , PdCl2(dppf) (47.9 mg, 0.065 mmol) and potassium acetate (64.2 mg, 0.654 mmol) in 1, 4-dioxane (3 ml) was stirred for 3 h at 80 . Then (R) -4-chloro-2- (4- (cyclopropanecarbonyl) -3-methylpiperazin-1-yl) pyrimidine-5-carbonitrile (29-a) (100 mg, 0.327 mmol) , potassium carbonate (90.1 mg, 0.654 mmol) and water (0.5 ml) were added and the resulting mixture was stirred for 5 h at 80 . The mixture was cooled, water (10 mL) was added and the mixture was extracted with ethyl acetate (3 x20 mL) . The combined organic fractions were washed with brine (3 x20 mL) , dried over sodium sulfate, filtered and concentrated under vacuum. The residue was purified by preparative-TLC, eluting with ethyl acetate: petroleum ether =1: 2 to give compound 6-13. MS (ESI) Calc?d for (C19H21N8O) [M+H]+, 377; found, 377.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[305,131],"tags":[126],"class_list":["post-1478","post","type-post","status-publish","format-standard","hentry","category-287922-71-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on 287922-71-8<\/title>\n<meta name=\"description\" content=\"Application of 287922-71-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 287922-71-8, name is 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1478\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Some tips on 287922-71-8\" \/>\n<meta property=\"og:description\" content=\"Application of 287922-71-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 287922-71-8, name is 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1478\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-13T17:36:14+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1478\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1478\",\"name\":\"Some tips on 287922-71-8\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-01-13T17:36:14+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Application of 287922-71-8, In the next few decades, the world population will flourish. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Some tips on 287922-71-8","description":"Application of 287922-71-8, In the next few decades, the world population will flourish. 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