{"id":1467,"date":"2021-01-13T01:38:38","date_gmt":"2021-01-12T17:38:38","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1467"},"modified":"2021-01-13T01:38:38","modified_gmt":"2021-01-12T17:38:38","slug":"introduction-of-a-new-synthetic-route-about-85290-80-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1467","title":{"rendered":"Introduction of a new synthetic route about 85290-80-8"},"content":{"rendered":"

Application of 85290-80-8<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 85290-80-8 as follows.<\/p>\n

Step 2 Preparation of 1-methyl-1H-pyrazole-4-carboxylic acid A solution of 1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (300 mg, 1.95 mmol) in ethanol cooled to 0\u00a1\u00e3 C. was treated with a 1N aqueous sodium hydroxide solution. The reaction was then warmed to 25\u00a1\u00e3 C. and was stirred at 25\u00a1\u00e3 C. for 18 h. At this time, the reaction was concentrated in vacuo and acidified to pH=2 with a 1N aqueous hydrochloric acid solution. This solution was extracted with ethyl acetate (3*50 mL). The organics were washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and dried in vacuo to afford 1-methyl-1H-pyrazole-4-carboxylic acid (193 mg, 78.5percent) as a white solid: LR-MS for C5H6N2O2 (M-H)+ at m\/z=125.<\/p>\n

According to the analysis of related databases, 85290-80-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 85290-80-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[302,131],"tags":[126],"class_list":["post-1467","post","type-post","status-publish","format-standard","hentry","category-85290-80-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 85290-80-8<\/title>\n<meta name=\"description\" content=\"Application of 85290-80-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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