{"id":1462,"date":"2021-01-13T01:38:38","date_gmt":"2021-01-12T17:38:38","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1462"},"modified":"2021-01-13T01:38:38","modified_gmt":"2021-01-12T17:38:38","slug":"new-downstream-synthetic-route-of-31728-75-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1462","title":{"rendered":"New downstream synthetic route of 31728-75-3"},"content":{"rendered":"

Some common heterocyclic compound, 31728-75-3, name is 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid<\/a><\/p>\n

The 4-amino-l,5-dimethyl-lH-pyrazole used as a starting material was prepared as follows :-Under an atmosphere of argon, diisopropylethylamine (3.49 ml) and diphenylphosphoryl azide (2.37 ml) were added in turn to a stirred mixture of 1 ,5-dimethyl-l\/J-pyrazole-4-carboxylic acid (1.4 g), fer\/-butanol (4 ml) and 1,4-dioxane (40 ml) and the reaction mixture was stirred at ambient temperature for 10 minutes. The resultant mixture was heated to 110C for 3 hours. The solvent was evaporated and the reaction product was purified by column chromatography on silica using ethyl acetate as the eluent. There was thus obtained 4-(fert-butoxycarbonylamino)- 1,5 -dimethyl- lH-pyrazole (0.225 g); 1H NMR: (DMSOd6) 1.4 (s, 9H), 2.2 (s, 3H), 3.55 (s, IH), 6.0 (br s, IH), 9.3 (br s, IH).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31728-75-3, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31728-75-3, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[299,131],"tags":[126],"class_list":["post-1462","post","type-post","status-publish","format-standard","hentry","category-31728-75-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of 31728-75-3<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 31728-75-3, name is 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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