{"id":1451,"date":"2021-01-12T01:38:19","date_gmt":"2021-01-11T17:38:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1451"},"modified":"2021-01-12T01:38:19","modified_gmt":"2021-01-11T17:38:19","slug":"sources-of-common-compounds-313735-62-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1451","title":{"rendered":"Sources of common compounds: 313735-62-5"},"content":{"rendered":"

Electric Literature of 313735-62-5<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 313735-62-5 name is 4-Bromo-1-isopropylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

4-bromo-1-(isopropyl)-1H-pyrazole 11d (200 mg, 1.06 mmol) was dissolved in dry THF (6 mL) at -78 Cunder nitrogen and was stirred for 10 min. n-BuLi (2.5 M in hexanes, 0.44 mL, 1.11 mmol) was added drop wise to the solution was stirred for 2 h at -78 C. After two hours, ethyl difluoroacetate (0.11 mL, 1.27 mmol) was added drop wise and stirred for 10 min at -78 C uponwhich the mixture was then quenched with NH4Cl (20 mL) and warmed to room temp. Themixture was then extracted with ether (50 mL), and dried over MgSO4. After concentration invacuo (note: remove shortly after the ether is removed, because the compound is quite volatile),the residue was purified with flash chromatography over silica gel (hexane: ethyl acetate =80:20) to yield the product as a clear oil in 48% yield (0.1 g).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-isopropylpyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-isopropylpyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[296,131],"tags":[126],"class_list":["post-1451","post","type-post","status-publish","format-standard","hentry","category-313735-62-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds: 313735-62-5<\/title>\n<meta name=\"description\" content=\"Electric Literature of 313735-62-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 313735-62-5 name is 4-Bromo-1-isopropylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1451\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds: 313735-62-5\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 313735-62-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 313735-62-5 name is 4-Bromo-1-isopropylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Sources of common compounds: 313735-62-5","description":"Electric Literature of 313735-62-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 313735-62-5 name is 4-Bromo-1-isopropylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=1451","og_locale":"en_US","og_type":"article","og_title":"Sources of common compounds: 313735-62-5","og_description":"Electric Literature of 313735-62-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 313735-62-5 name is 4-Bromo-1-isopropylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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