{"id":1424,"date":"2021-01-11T09:19:23","date_gmt":"2021-01-11T01:19:23","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1424"},"modified":"2021-01-11T09:19:23","modified_gmt":"2021-01-11T01:19:23","slug":"introduction-of-a-new-synthetic-route-about-51985-95-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1424","title":{"rendered":"Introduction of a new synthetic route about 51985-95-6"},"content":{"rendered":"

Electric Literature of 51985-95-6<\/a>, A common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a solution of methyl S-hydroxy-l-methyl-S-pyrazolecarboxylate (Sucrow, W.;Auffenberg-Weddige, K.; Grosz, K. P.; Bredthauer, G.; Pickardt, J. Chemische Berichte 1983, 116(4), 1525-30., 10 g, 64 mmol), in acetonitrile (200 ml) is added POBr3 (95g, 322 mmol) and the resulting mixture is heated in a sealed flask at 80 0C for 15 hours. After 15 hours the reaction mixture is cooled to room temperature and added to a cooled (0 0C) solution of saturated aqueous sodium bicarbonate. After the addition, the product is extracted into ethyl acetate 3x. The combined organic layers are decolorized with charcoal, dried (anhydrous Na2SO4), filtered and evaporated in vacuo to give the product as a brown oil, that solidified upon standing 11.5g, (72%), LC\/MS ESI m\/z (M+H)+ = 220.2.<\/p>\n

The synthetic route of 51985-95-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 51985-95-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[293,131],"tags":[126],"class_list":["post-1424","post","type-post","status-publish","format-standard","hentry","category-51985-95-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 51985-95-6<\/title>\n<meta name=\"description\" content=\"Electric Literature of 51985-95-6, A common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1424\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about 51985-95-6\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 51985-95-6, A common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1424\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-11T01:19:23+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1424\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1424\",\"name\":\"Introduction of a new synthetic route about 51985-95-6\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-01-11T01:19:23+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Electric Literature of 51985-95-6, A common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1424#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1424\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1424#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Introduction of a new synthetic route about 51985-95-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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