{"id":1396,"date":"2021-01-07T13:43:51","date_gmt":"2021-01-07T05:43:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1396"},"modified":"2021-01-07T13:43:51","modified_gmt":"2021-01-07T05:43:51","slug":"share-a-compound-28466-26-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1396","title":{"rendered":"Share a compound : 28466-26-4"},"content":{"rendered":"

28466-26-4, name is 4-Aminopyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 4-Aminopyrazole<\/a><\/p>\n

lH-Pyrazol-4-amine (10.4 g, 125 mmol) was dissolved in concentrated HCl (36.8 mL)\/water (186 mL) and cooled to 0C. A solution of sodium nitrite (9.05g, 131 mmol) in water (122 mL) was added dropwise while maintaining the internal temperature below 4C. On complete addition, the mixture was stirred at 0C for 30 min. The resulting diazonium chloride solution was added via a pipette to a solution of tert-butyl acetoacetate (21.8 mL, 131 mmol) and sodium acetate (124 g, 1.51 mol) in water (122 mL) and EtOH (122 mL) at 0C. The resulting mixture was stirred between 0-1 C for two hours. The solid was filtered and dried in-vacuo to afford terf -butyl 3-oxo-2-[lH-pyrazol-4-yldiazenyl]butanoate as a yellow-brownish powder. LRMS (ESI) calc’d for CI 1Eta17Nu403 [M+H]+: 253, Found: 253.<\/p>\n

The synthetic route of 28466-26-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 28466-26-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[144,131],"tags":[145],"class_list":["post-1396","post","type-post","status-publish","format-standard","hentry","category-28466-26-4","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nShare a compound : 28466-26-4<\/title>\n<meta name=\"description\" content=\"28466-26-4, name is 4-Aminopyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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