{"id":1390,"date":"2021-01-06T10:56:35","date_gmt":"2021-01-06T02:56:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1390"},"modified":"2021-01-06T10:56:35","modified_gmt":"2021-01-06T02:56:35","slug":"some-tips-on-402-61-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1390","title":{"rendered":"Some tips on 402-61-9"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6N2O2<\/a><\/p>\n

A mixture of 5-methyl-1H-pyrazole-3-carboxylic acid (27) (150 mg, 1.19 mmol), EDCI\u00a1\u00a4HCl (228 mg, 1.19 mmol), HOBt\u00a1\u00a4H2O (182 mg, 1.19 mmol) and DIPEA (0.20 mL, 1.19 mmol) in DMF was cooled to 0 C and 3,3′,5,5′-tetrakis(aminomethyl)-2,2′,4,4′,6,6′-hexamethyldiphenylmethane (22) (100 mg, 0.27 mmol), dissolved in DMF (3 mL), was added dropwise. The reaction mixture was stirred for 5 days at room temperature and afterwards poured into ice water (80 mL), the formed precipitate filtered off, washed thoroughly with distilled water and dried in the desiccator to constant mass. The desired compound was obtained as a white solid (180 mg, 83%), mp 216 C. 1H NMR (400 MHz, CD3OD): delta 6.46 (s, 4H), 4.57 (s, 8H), 4.23 (s, 2H), 2.39 (s, 6H), 2.28 (s, 12H), 2.10 (s, 12H) ppm. 13C NMR (100 MHz, CD3OD): delta 164.60, 147.86, 141.94, 139.39, 137.51, 135.77, 133.58, 105.48, 39.79, 34.29, 17.38, 16.22, 10.46 ppm. HRMS (ESI) calcd for C43H52N12O4Na [M+Na]+ 823.41267, found 823.41306.<\/p>\n

According to the analysis of related databases, 402-61-9, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 402-61-9, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[159,131],"tags":[126],"class_list":["post-1390","post","type-post","status-publish","format-standard","hentry","category-402-61-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on 402-61-9<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. 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