{"id":1383,"date":"2021-01-06T10:56:35","date_gmt":"2021-01-06T02:56:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1383"},"modified":"2021-01-06T10:56:35","modified_gmt":"2021-01-06T02:56:35","slug":"share-a-compound-138786-86-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1383","title":{"rendered":"Share a compound : 138786-86-4"},"content":{"rendered":"

These common heterocyclic compound, 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H5N3O4<\/a><\/p>\n

A solution of methyl 4-nitro-lH-pyrazole-3-carboxylate (54.Og, 315.6 mmol), phenylboronic acid (77.Og, 631.2 mmol), copper(II) acetate (86.Og, 473.4 mmol) and pyridine (49.9g, 631.2 mmol) in methylene chloride (600 mL) was stirred at ambient temperature open to air for 48 hours. The reaction was evaporated in vacuo, diluted with 100OmL methylene chloride and filtered through a large plug of silica (washing with 2 liters methylene chloride). The solvent was evaporated in vacuo. 1H NMR (CDCIa) S8.61 (s, IH), 7.73 (m, 2H), 7.50 (m, 3H), 4.02 (s, 3H)<\/p>\n

The synthetic route of Methyl 4-nitro-1H-pyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of Methyl 4-nitro-1H-pyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[271,131],"tags":[126],"class_list":["post-1383","post","type-post","status-publish","format-standard","hentry","category-138786-86-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 138786-86-4<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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