{"id":1377,"date":"2021-01-05T16:52:55","date_gmt":"2021-01-05T08:52:55","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1377"},"modified":"2021-01-05T16:52:55","modified_gmt":"2021-01-05T08:52:55","slug":"introduction-of-a-new-synthetic-route-about-10250-64-3-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1377","title":{"rendered":"Introduction of a new synthetic route about 10250-64-3"},"content":{"rendered":"

These common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 10250-64-3<\/a><\/p>\n

General procedure: To a solution of 19 (1.2 eq) and HOBt(1.4 eq) in DMF (0.5 M) were added EDCI (1.3 eq) and a solution of 15a-j or 16a-j (1.0 eq) in DMF (0.25 M), Et3N (3.5 eq) at 0 C. The reaction mixture was stirred at room temperature for 24 hours, then diluted in AcOEt. The organic phase was washed with water twice, saturated aqueous NaHCO3 three times, and brine, then dried over Na2SO4,filtered, and concentrated. The residue was purified by flash column chromatography to give intermediates 17a-j and 18a-j.<\/p>\n

The synthetic route of 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[135,131],"tags":[127],"class_list":["post-1377","post","type-post","status-publish","format-standard","hentry","category-10250-64-3","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nIntroduction of a new synthetic route about 10250-64-3<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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