{"id":1315,"date":"2020-12-30T10:56:08","date_gmt":"2020-12-30T02:56:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1315"},"modified":"2020-12-30T10:56:08","modified_gmt":"2020-12-30T02:56:08","slug":"the-important-role-of-34605-66-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1315","title":{"rendered":"The important role of 34605-66-8"},"content":{"rendered":"

34605-66-8, name is 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C10H13N3<\/a><\/p>\n

At -78 C, to a solution of 3-(2,5-di methyl- 1 \/7-pyrrol- 1 -yl)- 1 -methyl- 1 \/7-pyrazolc (step 1 intermediate) (2.0 g, 11.4 mmol) was added n-butyl lithium (1.6 M, 10.55 mL, 16.8 mmol) and the mixture was continued to stir at -78 C for 30 min. The mixture was stirred for 2 h at 0 C and added acetone (1.28 mL, 17.5 mmol) to the solution. The mixture was stirred at RT for 3 h. The mixture was quenched with water and extracted with ethyl acetate. The organic phase was washed with brine and dried over anhydrous sodium sulfate. The solution was filtered, concentrated and the residue obtained was purified by column chromatography to yield 1.0 g of the desired compound. NMR (400 MHz, DMSO-de) d 1.54 (s, 6H), 2.04 (s, 6H), 3.98 (s, 3H), 5.42 (s, 1H), 5.73 (s, 2H), 6.10 (s, 1H).<\/p>\n

The synthetic route of 34605-66-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 34605-66-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269,131],"tags":[126],"class_list":["post-1315","post","type-post","status-publish","format-standard","hentry","category-34605-66-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 34605-66-8<\/title>\n<meta name=\"description\" content=\"34605-66-8, name is 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C10H13N3\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1315\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 34605-66-8\" \/>\n<meta property=\"og:description\" content=\"34605-66-8, name is 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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