{"id":1274,"date":"2020-12-24T10:38:18","date_gmt":"2020-12-24T02:38:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1274"},"modified":"2020-12-24T10:38:18","modified_gmt":"2020-12-24T02:38:18","slug":"extracurricular-laboratory-synthetic-route-of-3398-16-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1274","title":{"rendered":"Extracurricular laboratory: Synthetic route of 3398-16-1"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3398-16-1 as follows. SDS of cas: 3398-16-1<\/a><\/p>\n

Step 6: 4-[3- (Cyanomethyl)-3- (3 ?.5 ?-dimethyl-JFL 1 ?H-4, 4 ?-bipyrazol-l-yl)azetidin-l-yl]2, 5-d ifluoro-N-[ (1S)-2, 2, 2-trifluoro-1-methylethyl]benzamideA mixture of 4- {3 -(cyanomethyl)-3 – [4-(4,4,5 ,5 -tetramethyl- 1,3 ,2-dioxaborolan-2- yl)- 1H-pyrazol- 1 -yl] azetidin- 1 -yl} -2,5 -difluoro-N- [(1 S)-2,2,2-trifluoro- 1- methylethyl]benzamide (329 mg, 0.610 mmol), 4-bromo-3 ,5 -dimethyl- 1 H-pyrazole (206 mg, 1.18 mmol), tetrakis(triphenylphosphine)palladium(0) (110 mg, 0.098 mmol) and sodium carbonate (320 mg, 3.0 mmol) in 1,4-dioxane (10 mL)\/water (5 mL) was purgedwith nitrogen and stirred at 110 \u00a1\u00e3C for 1 h. The reaction mixture was diluted with EtOAc, washed with water and brine, concentrated. The residue was purified first with silica gel (eluting with 0-100percent EtOAc\/hexanes followed by 10percent methanol\/dichloromethane), and then by prep-LCMS (XBridge Cl 8 column, eluting with a gradient of acetonitrile\/water containing 0.1percent ammonium hydroxide, at flow rate of 60 mL\/min) to give the desiredproduct (30 mg, 9.7percent). ?H NMR (500 MHz, DMSO-d6) oe 12.17 (1H, s), 8.45 (1H, d, J8.0 Hz), 8.10 (1H, s), 7.70 (1H, s), 7.34 (1H, m), 6.61 (1H, s), 4.77 (1H, m), 4.62 (2H, d, J= 9.0 Hz), 4.39 (1H, d, J= 9.0 Hz), 3.64 (2H, s), 2.22 (6H, s), 1.31 (6H, d, J 7.0 Hz) ppm. LCMS calculated for C23H23F5N70 (M+H): mlz = 508.2; Found: 508.0.<\/p>\n

According to the analysis of related databases, 3398-16-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 3398-16-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[250,131],"tags":[126],"class_list":["post-1274","post","type-post","status-publish","format-standard","hentry","category-3398-16-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of 3398-16-1<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3398-16-1 as follows. 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