{"id":1259,"date":"2020-12-23T10:33:07","date_gmt":"2020-12-23T02:33:07","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1259"},"modified":"2020-12-23T10:33:07","modified_gmt":"2020-12-23T02:33:07","slug":"the-important-role-of-89181-79-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1259","title":{"rendered":"The important role of 89181-79-3"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89181-79-3, name is 3-Amino-1-methyl-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 3-Amino-1-methyl-1H-pyrazole-4-carboxamide<\/a><\/p>\n

A solution of 2,2-difluoro-2-(4-fluorophenyl) acetic acid(prepared according to Middleton et al, J. Org. Chem., 1980, 45(14); 2883-2887 by reaction of ethyl 2-(4-fluorophenyl)-2-oxoacetate with (diethylamino)sulfur trifluoride followed by ester saponification) (136 mg, 0.71 mmol) and HATU (380 mg, 0.86 mmol) in THF (1.5 mL) was stirred at rt for 10 min. 3-Amino-l-methyl-lH-pyrazole- 4-carboxamide (100 mg, 0.71 mmol) and TEA (87 mg, 0.86 mmol) were added and the mixture was stirred at rt overnight. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in EtOAc and washed with aq NH4CI and brine. The organic layer was separated and concentrated under reduced pressure to afford 3-(2,2-difluoro-2-(4-fluorophenyl)acetamido)-l-methyl-lH-pyrazole-4- carboxamide (170 mg, 76%) as a yellow solid. H NMR (300 MHz, DMSO-t 6) delta 11.29 (s, 1H), 8.15 (s, 1H), 7.71-7.75 (m, 3H), 7.41 (t, 2H), 7.32 (br s, 1H), 3.81 (s, 3H). LCMS (ESI) m\/z 311 (M – H)~.<\/p>\n

The synthetic route of 89181-79-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 89181-79-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[247,131],"tags":[126],"class_list":["post-1259","post","type-post","status-publish","format-standard","hentry","category-89181-79-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 89181-79-3<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89181-79-3, name is 3-Amino-1-methyl-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The important role of 89181-79-3","description":"In the next few decades, the world population will flourish. 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