{"id":1239,"date":"2020-12-21T11:16:49","date_gmt":"2020-12-21T03:16:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1239"},"modified":"2020-12-21T11:16:49","modified_gmt":"2020-12-21T03:16:49","slug":"application-of-1018446-95-1-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1239","title":{"rendered":"Application of 1018446-95-1"},"content":{"rendered":"

Some common heterocyclic compound, 1018446-95-1, name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, molecular formula is C8H13N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1018446-95-1<\/a><\/p>\n

Tert-butyl 4-amino-1H-pyrazole-1-carboxylate (24 mg, which was synthesized according to W02008\/139161), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (21 mg), cesium carbonate (97 mg), and tris(dibenzylideneacetone)dipalladium (0) (16 mg) were added to a solution of the compound 0001-5 (40 mg) in 1,4-dioxane solution (1.2 mL), and the mixture was heated and refluxed for 2 hours under a nitrogen atmosphere. The reaction solution was returned to room temperature, water was added thereto, and the mixture was extracted with a chloroform-methanol mixed solvent. The organic layer was dried over sodium sulfate and the solvent was then evaporated under reduced pressure. To the obtained residue, dichloromethane (1.2 mL) and trifluoroacetic acid (0.18 mL) were added, and the mixture was stirred at room temperature for 6 hours. Then, a saturated aqueous sodium hydrogen carbonate solution was added to the reaction solution, and the mixture was extracted with a chloroform-methanol mixed solvent. The organic layer was dried over sodium sulfate, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform-methanol) to obtain a compound 0125 (18 mg) as a yellow solid. 1H-NMR (DMSO-d6) delta: 12.80 (1H, bs), 9.58 (1H, s), 9.51 (1H, bd), 8.42-8.41 (2H, m), 8.00 (1H, d), 7.85 (1H, bs), 7.53 (1H, bs), 7.12 (1H, d), 7.03 (1H, d), 4.14-4.03 (1H, m), 1.93-1.46 (8H, m). MS m\/z (M+H): 338.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1018446-95-1, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1018446-95-1, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[238,131],"tags":[126],"class_list":["post-1239","post","type-post","status-publish","format-standard","hentry","category-1018446-95-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of 1018446-95-1<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 1018446-95-1, name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, molecular formula is C8H13N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1018446-95-1\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1239\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Application of 1018446-95-1\" \/>\n<meta property=\"og:description\" content=\"Some common heterocyclic compound, 1018446-95-1, name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, molecular formula is C8H13N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1018446-95-1\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1239\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-21T03:16:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1239\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1239\",\"name\":\"Application of 1018446-95-1\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-12-21T03:16:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Some common heterocyclic compound, 1018446-95-1, name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, molecular formula is C8H13N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1018446-95-1\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1239#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1239\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1239#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Application of 1018446-95-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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