{"id":1235,"date":"2020-12-21T11:16:49","date_gmt":"2020-12-21T03:16:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1235"},"modified":"2020-12-21T11:16:49","modified_gmt":"2020-12-21T03:16:49","slug":"brief-introduction-of-19959-77-4-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1235","title":{"rendered":"Brief introduction of 19959-77-4"},"content":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, I believe this compound will play a more active role in future production and life. 19959-77-4<\/a><\/p>\n

To a solution of 2-(5-methyl-1H-pyrazol-3-yl)pyridine (27.9 g, 175 mmol) in carbon tetrachloride (300 mL) and dicholoromethane (300 mL) in a round-bottom flask was added N-bromosuccunimide (31.2 g, 175 mmol). The resulting mixture was stirred at room temperature for 21 hours and the reaction mixture was added water. The resulting solution was extracted with dicholomethane. The organic extracts were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting solid was washed with hexane\/AcOEt (v\/v =10\/1) and dried under reduced pressure at 50 C. The title compound was obtained as a white solid. (37.5 g, 158 mmol, 90% yield): 1H NMR (400 MHz, CDCl3) d 8.61 (d, J = 3.1 Hz, 1H), 8.28 (d, J = 7.8 Hz, 1H), 7.80 (t, J = 7.8 Hz, 1H), 7.28 (t, J = 7.8 Hz, 1H), 2.34 (s, 3H).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 19959-77-4. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 19959-77-4. 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