{"id":1233,"date":"2020-12-21T11:12:57","date_gmt":"2020-12-21T03:12:57","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1233"},"modified":"2020-12-21T11:12:57","modified_gmt":"2020-12-21T03:12:57","slug":"new-learning-discoveries-about-16034-46-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1233","title":{"rendered":"New learning discoveries about 16034-46-1"},"content":{"rendered":"

16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 16034-46-1<\/a><\/p>\n

Oleum (1977mmol) is slowly added to fuming nitric acid (777 mmol) followed by the addition of 2-methyl-2H-pyrazole-3-carboxylic acid (277 mmol) in small portions maintaining the reaction temperature below 600C. Stirring at this temperature is then continued for a further 1 h. On completion, the reaction mixture is poured onto crushed ice and extracted with ethyl acetate (300 mL x 3). The combined organic phases are washed with water (250 mL x 2) and dried over anhydrous sodium sulfate. The solvent is removed under reduced pressure to afford 2-methyl-4-nitro-2H-pyrazole-3- carboxylic acid as a light yellow solid. Compound wt: 23.6g, 50%. [0234] 1H NMR (400 MHz, OMSO-d6) delta: 8.29 (lH,s); 3.95 (3H, s).<\/p>\n

Statistics shows that 16034-46-1 is playing an increasingly important role. we look forward to future research findings about 1-Methyl-1H-pyrazole-5-carboxylic acid.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 16034-46-1 is playing an increasingly important role. we look forward to future research findings about 1-Methyl-1H-pyrazole-5-carboxylic acid.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[169,131],"tags":[126],"class_list":["post-1233","post","type-post","status-publish","format-standard","hentry","category-16034-46-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew learning discoveries about 16034-46-1<\/title>\n<meta name=\"description\" content=\"16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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