{"id":12305,"date":"2024-06-14T03:29:54","date_gmt":"2024-06-13T19:29:54","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12305"},"modified":"2024-10-21T19:05:42","modified_gmt":"2024-10-21T11:05:42","slug":"antuganov-dmitrii-et-al-published-their-research-in-european-journal-of-organic-chemistry-in-2019-cas-936902-12-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12305","title":{"rendered":"Antuganov, Dmitrii et al. published their research in European Journal of Organic Chemistry in 2019 | CAS: 936902-12-4"},"content":{"rendered":"<p>Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates was written by Antuganov, Dmitrii;Zykov, Michail;Timofeev, Vasilii;Timofeeva, Ksenija;Antuganova, Yulija;Orlovskaya, Victoriya;Fedorova, Olga;Krasikova, Raisa. And the article was included in European Journal of Organic Chemistry in 2019.<a href=\"https:\/\/www.ambeed.com\/products\/936902-12-4.html\">Application of 936902-12-4<\/a> This article mentions the following:<\/p>\n<p>Radiofluorination of arylboronic acids pinacol esters (arylBPin) mediated by copper triflate pyridine complex is one of the more promising synthetic approaches for the direct introduction of nucleophilic [<sup>18<\/sup>F]fluoride into non-activated arenes and heteroarenes. However, the application of this method to the production of positron emission tomog. (PET) radiotracers in automated synthesizers remains a challenging task. The choice of phase-transfer catalyst (PTC) and corresponding base used for the generation of reactive [<sup>18<\/sup>F]fluoride species has a profound impact on the efficiency of the <sup>18<\/sup>F-fluorination process. Herein the authors report the development of a simple procedure involving trapping of the aqueous [<sup>18<\/sup>F]fluoride on a weak anion-exchange resin (WAX) and its release by elution with pyridinium sulfonate in di-Me acetamide. Obtained reactive [<sup>18<\/sup>F]fluoride was used as-is in a copper-catalyzed fluorination reaction employing pyridinium salt as both PTC and base. High radiochem. conversion rates (RCCs) achieved for a series of simple arylBPin substrates and 4-[<sup>18<\/sup>F]fluoro-D,L-phenylalanine demonstrate the efficiency of this novel <sup>18<\/sup>F-processing approach. Notably, the proposed method obviates conventional azeotropic drying steps, solvents evaporation and\/or changeover and can be implemented on com. automated synthesizers. In the experiment, the researchers used many compounds, for example, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (cas: 936902-12-4<a href=\"https:\/\/www.ambeed.com\/products\/936902-12-4.html\">Application of 936902-12-4<\/a>).<\/p>\n<p>5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (cas: 936902-12-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)\u2014flunoxaprofen, benoxaprofen, antibiotic\u2014calcimycin.<a href=\"https:\/\/www.ambeed.com\/products\/936902-12-4.html\">Application of 936902-12-4<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Benzoxazole\">Benzoxazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/benzoxazole\">Benzoxazole | C7H5NO &#8211; PubChem<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (cas: 936902-12-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)\u2014flunoxaprofen, benoxaprofen, antibiotic\u2014calcimycin.<a href=\"https:\/\/www.ambeed.com\/products\/936902-12-4.html\">Application of 936902-12-4<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[845,841],"tags":[846],"class_list":["post-12305","post","type-post","status-publish","format-standard","hentry","category-936902-12-4","category-benzoxazole","tag-245-082"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antuganov, Dmitrii et al. published their research in European Journal of Organic Chemistry in 2019 | CAS: 936902-12-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates was written by Antuganov, Dmitrii;Zykov, Michail;Timofeev, Vasilii;Timofeeva, Ksenija;Antuganova, Yulija;Orlovskaya, Victoriya;Fedorova, Olga;Krasikova, Raisa. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Antuganov, Dmitrii et al. published their research in European Journal of Organic Chemistry in 2019 | CAS: 936902-12-4 | pyrazoles-derivatives","description":"Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates was written by Antuganov, Dmitrii;Zykov, Michail;Timofeev, Vasilii;Timofeeva, Ksenija;Antuganova, Yulija;Orlovskaya, Victoriya;Fedorova, Olga;Krasikova, Raisa. And the article was included in European Journal of Organic Chemistry in 2019.Application of 936902-12-4 This article mentions the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=12305","og_locale":"en_US","og_type":"article","og_title":"Antuganov, Dmitrii et al. published their research in European Journal of Organic Chemistry in 2019 | CAS: 936902-12-4 | pyrazoles-derivatives","og_description":"Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates was written by Antuganov, Dmitrii;Zykov, Michail;Timofeev, Vasilii;Timofeeva, Ksenija;Antuganova, Yulija;Orlovskaya, Victoriya;Fedorova, Olga;Krasikova, Raisa. And the article was included in European Journal of Organic Chemistry in 2019.Application of 936902-12-4 This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12305","og_site_name":"pyrazoles-derivatives","article_published_time":"2024-06-13T19:29:54+00:00","article_modified_time":"2024-10-21T11:05:42+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12305","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12305","name":"Antuganov, Dmitrii et al. published their research in European Journal of Organic Chemistry in 2019 | CAS: 936902-12-4 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2024-06-13T19:29:54+00:00","dateModified":"2024-10-21T11:05:42+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates was written by Antuganov, Dmitrii;Zykov, Michail;Timofeev, Vasilii;Timofeeva, Ksenija;Antuganova, Yulija;Orlovskaya, Victoriya;Fedorova, Olga;Krasikova, Raisa. And the article was included in European Journal of Organic Chemistry in 2019.Application of 936902-12-4 This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12305#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=12305"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12305#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Antuganov, Dmitrii et al. published their research in European Journal of Organic Chemistry in 2019 | CAS: 936902-12-4"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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