{"id":12285,"date":"2023-12-20T04:21:32","date_gmt":"2023-12-19T20:21:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12285"},"modified":"2024-10-21T19:09:07","modified_gmt":"2024-10-21T11:09:07","slug":"hillers-s-et-al-published-their-research-in-khimiya-geterotsiklicheskikh-soedinenii-in-1975-cas-55361-49-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12285","title":{"rendered":"Hillers, S. et al. published their research in Khimiya Geterotsiklicheskikh Soedinenii in 1975 | CAS: 55361-49-4"},"content":{"rendered":"<p>Reaction of \u6d7c?chloroacrylonitrile with hydrazines was written by Hillers, S.;Eremeev, A. V.;Kalvins, I.;Liepins, E.;Tikhomirov, D. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Category: pyrazoles-derivatives<\/a> This article mentions the following:<\/p>\n<p>Pyrazoles (I; R = NH2, R1 = H, Et, R2 = H) were prepared in 50-60% yields by treatment of N2H4 and EtNHNH2 with CH2:CClCN (II) in dry Et2O at room temperature Treatment of II with PhNHNH2 gave 85% PhNHNHCH2CHClCN which was cyclized by NaOMe-MeOH to give 30% I (R = H, R1 = Ph, R2 = NH2). Treatment of II with Me2NNH2 gave 40-51% Me2NNHCH2CHClCN. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Category: pyrazoles-derivatives<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Category: pyrazoles-derivatives<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Category: pyrazoles-derivatives<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[832,131],"tags":[128],"class_list":["post-12285","post","type-post","status-publish","format-standard","hentry","category-55361-49-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hillers, S. et al. published their research in Khimiya Geterotsiklicheskikh Soedinenii in 1975 | CAS: 55361-49-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Reaction of \u6d7c?chloroacrylonitrile with hydrazines was written by Hillers, S.;Eremeev, A. V.;Kalvins, I.;Liepins, E.;Tikhomirov, D. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.Category: pyrazoles-derivatives This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12285\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hillers, S. et al. published their research in Khimiya Geterotsiklicheskikh Soedinenii in 1975 | CAS: 55361-49-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Reaction of \u6d7c?chloroacrylonitrile with hydrazines was written by Hillers, S.;Eremeev, A. V.;Kalvins, I.;Liepins, E.;Tikhomirov, D. A.. 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