{"id":12283,"date":"2024-02-13T04:21:32","date_gmt":"2024-02-12T20:21:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12283"},"modified":"2024-10-21T19:08:50","modified_gmt":"2024-10-21T11:08:50","slug":"abdou-ibrahim-m-et-al-published-their-research-in-molecules-in-2004-cas-401-73-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12283","title":{"rendered":"Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0"},"content":{"rendered":"<p>Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one<\/a> This article mentions the following:<\/p>\n<p>2,4-Dihydropyrazole glucosides were prepared and tested for their antitumor activity. The structures of these compounds were established by <sup>1<\/sup>H and <sup>13<\/sup>C- NMR spectroscopy. The para-fluoro glucoside shows an in vitro IC<sub>50<\/sub> value of 16.4 \u5a13\u748f against proliferation of the human promyelotic leukemia (HL60) cell line. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one<\/a>).<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[834,131],"tags":[128],"class_list":["post-12283","post","type-post","status-publish","format-standard","hentry","category-401-73-0","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12283\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12283\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2024-02-12T20:21:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-21T11:08:50+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12283\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12283\",\"name\":\"Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2024-02-12T20:21:32+00:00\",\"dateModified\":\"2024-10-21T11:08:50+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12283#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=12283\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12283#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0 | pyrazoles-derivatives","description":"Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=12283","og_locale":"en_US","og_type":"article","og_title":"Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0 | pyrazoles-derivatives","og_description":"Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12283","og_site_name":"pyrazoles-derivatives","article_published_time":"2024-02-12T20:21:32+00:00","article_modified_time":"2024-10-21T11:08:50+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12283","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12283","name":"Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2024-02-12T20:21:32+00:00","dateModified":"2024-10-21T11:08:50+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12283#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=12283"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12283#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Abdou, Ibrahim M. et al. published their research in Molecules in 2004 | CAS: 401-73-0"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/12283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12283"}],"version-history":[{"count":1,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/12283\/revisions"}],"predecessor-version":[{"id":12316,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/12283\/revisions\/12316"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}