{"id":12273,"date":"2023-02-13T04:19:39","date_gmt":"2023-02-12T20:19:39","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12273"},"modified":"2023-02-13T04:19:39","modified_gmt":"2023-02-12T20:19:39","slug":"zhang-xin-ke-et-al-published-their-research-in-advanced-synthesis-catalysis-in-2021-cas-3528-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12273","title":{"rendered":"Zhang, Xin-Ke et al. published their research in Advanced Synthesis &amp; Catalysis in 2021 | CAS: 3528-58-3"},"content":{"rendered":"<p>Iodine-Promoted Synthesis of Dipyrazolo\/Diuracil-Fused Pyridines and o-Amino Diheteroaryl ketones via Oxidative Domino Annulation of 2\/4-Methylazaarenes was written by Zhang, Xin-Ke;Miao, Xiao-Yu;Jiang, Hui-Ru;Ge, Fei;Sun, Jia-Chen;Zhang, Rui-Ying;Ouyang, Qin;Fan, Wei-Yu;Zthu, Yan-Ping;Sun, Yuan-Yuan. And the article was included in Advanced Synthesis &amp; Catalysis in 2021.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine<\/a> This article mentions the following:<\/p>\n<p>The iodine-promoted oxidative domino annulation and carbonylation process has been developed for the synthesis of biol. important azaarene-substituted bis-pyrazolo[3,4-b:4&#8242;,3&#8242;-e]pyridines (BPPs) <strong>I<\/strong> (R = quinolin-2-yl, 1,3-benzoxazol-2-yl, pyridin-4-yl, etc.; R<sup>1<\/sup> = Me, Ph, t-Bu, 4-fluorophenyl; R<sup>2<\/sup> = H, Ph, 2,5-dimethylphenyl, 4-methylphenyl), diuracilpyridines <strong>II<\/strong> [R<sup>3<\/sup> = 7-fluoroquinolin-2-yl, 1,8-naphthyridin-2-yl, 1,3-benzothiazol-2-yl, etc.] and o-amino diheteroaryl ketones <strong>III<\/strong> [R<sup>4<\/sup> = H, Me, Cl, OEt, etc.; R<sup>5<\/sup> = H, Me; R<sup>6<\/sup> = Me, Et, Ph]. The domino procedure proceeded with easily available Me azaarenes such as 2-Me quinoline, 2-methylquinazolin-4(3H)-one, 2-methylbenzothiazole, etc. 6-amino-1,3-dimethylpyrimidine-2,4-dione and substituted 5-aminopyrazoles <strong>IV<\/strong> (R<sup>7<\/sup> = H, Me, Ph, t-Bu, etc.; R<sup>8<\/sup> = H, Me, Et, Ph, etc.). This protocol is a simple and metal-free approach which exhibits high functional group compatibility and broad substrates scope. Moreover, this transformation can be applied for the preparation of dipyrazolo\/diuracil-fused pyridines <strong>I<\/strong> (R = quinolin-2-yl; R<sup>1<\/sup> = Me; R<sup>2<\/sup> = Ph)\/<strong>II<\/strong> (R<sup>3<\/sup> = quinolin-2-yl) on a gram scale. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[830,131],"tags":[128],"class_list":["post-12273","post","type-post","status-publish","format-standard","hentry","category-3528-58-3","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Zhang, Xin-Ke et al. published their research in Advanced Synthesis &amp; Catalysis in 2021 | CAS: 3528-58-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Iodine-Promoted Synthesis of Dipyrazolo\/Diuracil-Fused Pyridines and o-Amino Diheteroaryl ketones via Oxidative Domino Annulation of 2\/4-Methylazaarenes was written by Zhang, Xin-Ke;Miao, Xiao-Yu;Jiang, Hui-Ru;Ge, Fei;Sun, Jia-Chen;Zhang, Rui-Ying;Ouyang, Qin;Fan, Wei-Yu;Zthu, Yan-Ping;Sun, Yuan-Yuan. 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And the article was included in Advanced Synthesis &amp; Catalysis in 2021.Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine This article mentions the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=12273","og_locale":"en_US","og_type":"article","og_title":"Zhang, Xin-Ke et al. published their research in Advanced Synthesis &amp; Catalysis in 2021 | CAS: 3528-58-3 | pyrazoles-derivatives","og_description":"Iodine-Promoted Synthesis of Dipyrazolo\/Diuracil-Fused Pyridines and o-Amino Diheteroaryl ketones via Oxidative Domino Annulation of 2\/4-Methylazaarenes was written by Zhang, Xin-Ke;Miao, Xiao-Yu;Jiang, Hui-Ru;Ge, Fei;Sun, Jia-Chen;Zhang, Rui-Ying;Ouyang, Qin;Fan, Wei-Yu;Zthu, Yan-Ping;Sun, Yuan-Yuan. 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