{"id":12270,"date":"2023-02-13T04:19:39","date_gmt":"2023-02-12T20:19:39","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12270"},"modified":"2023-02-13T04:19:39","modified_gmt":"2023-02-12T20:19:39","slug":"dalinger-i-l-et-al-published-their-research-in-izvestiya-akademii-nauk-seriya-khimicheskaya-in-1993-cas-5334-39-4-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12270","title":{"rendered":"Dalinger, I. L. et al. published their research in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1993 | CAS: 5334-39-4"},"content":{"rendered":"<p>Nitropyrazoles. 3. Synthesis of C-(diformylmethyl)nitropyrazoles was written by Dalinger, I. L.;Shkineva, T. K.;Shevelev, S. A.;Krat, V.;Arnold, Z.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1993.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Category: pyrazoles-derivatives<\/a> This article mentions the following:<\/p>\n<p>A double Vilsmeier formylation of a C-Me group in pyrazole derivatives occurs when a nitro group is adjacent to the Me group. Thus, dimethylnitropyrazole <strong>I<\/strong> was treated with DMF and POCl<sub>3<\/sub> to give diperchlorate <strong>II<\/strong>, which was hydrolyzed to bis(diformylmethyl) derivative <strong>III<\/strong>. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Category: pyrazoles-derivatives<\/a>).<\/p>\n<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Category: pyrazoles-derivatives<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Category: pyrazoles-derivatives<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[216,131],"tags":[128],"class_list":["post-12270","post","type-post","status-publish","format-standard","hentry","category-5334-39-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dalinger, I. L. et al. published their research in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1993 | CAS: 5334-39-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Nitropyrazoles. 3. Synthesis of C-(diformylmethyl)nitropyrazoles was written by Dalinger, I. L.;Shkineva, T. K.;Shevelev, S. A.;Krat, V.;Arnold, Z.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1993.Category: pyrazoles-derivatives This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12270\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dalinger, I. L. et al. published their research in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1993 | CAS: 5334-39-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Nitropyrazoles. 3. Synthesis of C-(diformylmethyl)nitropyrazoles was written by Dalinger, I. L.;Shkineva, T. K.;Shevelev, S. A.;Krat, V.;Arnold, Z.. 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