{"id":12269,"date":"2023-02-13T04:19:39","date_gmt":"2023-02-12T20:19:39","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12269"},"modified":"2023-02-13T04:19:39","modified_gmt":"2023-02-12T20:19:39","slug":"osawa-akio-et-al-published-their-research-in-chemical-pharmaceutical-bulletin-in-1988-cas-15953-73-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12269","title":{"rendered":"Osawa, Akio et al. published their research in Chemical &amp; Pharmaceutical Bulletin in 1988 | CAS: 15953-73-8"},"content":{"rendered":"<p>Reactions of N-aminopyrazoles with halogenating reagents and synthesis of 1,2,3-triazines was written by Osawa, Akio;Kaiho, Terumitsu;Ito, Takashi;Okada, Mamiko;Kawabata, Chikako;Yamaguchi, Kentaro;Igeta, Hiroshi. And the article was included in Chemical &amp; Pharmaceutical Bulletin in 1988.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">Synthetic Route of C5H7ClN2<\/a> This article mentions the following:<\/p>\n<p>Reactions of <em>N<\/em>-aminopyrazoles with halogenating reagents (Cl<sub>2<\/sub>, Br<sub>2<\/sub>, I<sub>2<\/sub>, BrCl, ICl, IBr, <em>N<\/em>-chlorosuccinimide, and <em>N<\/em>-bromosuccinimide) were examined Some of these reagents preferentially leas to oxidation of the amino group to give the corresponding 1,2,3-triazines as major products, while others mainly gave either or both of 1-amino-4-halopyrazoles and 5-halo-1,2,3-triazines as the result of halogenation of the 4-position of the pyrazole ring prior to the oxidation of the amino group. In some cases, the oxidation of the amino group and the halogenation of the pyrazole ring proceeded concurrently to form not only the unhalogenated triazines but also the 1-amino-4-halopyrazines and the 5-halotriazines. Various reagents and reaction conditions were explored to utilize the reaction for the synthesis of halogenated and unhalogenated 1,2,3-triazines. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">Synthetic Route of C5H7ClN2<\/a>).<\/p>\n<p>4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">Synthetic Route of C5H7ClN2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">Synthetic Route of C5H7ClN2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[835,131],"tags":[128],"class_list":["post-12269","post","type-post","status-publish","format-standard","hentry","category-15953-73-8","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Osawa, Akio et al. published their research in Chemical &amp; Pharmaceutical Bulletin in 1988 | CAS: 15953-73-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Reactions of N-aminopyrazoles with halogenating reagents and synthesis of 1,2,3-triazines was written by Osawa, Akio;Kaiho, Terumitsu;Ito, Takashi;Okada, Mamiko;Kawabata, Chikako;Yamaguchi, Kentaro;Igeta, Hiroshi. 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