{"id":12265,"date":"2023-02-13T04:19:39","date_gmt":"2023-02-12T20:19:39","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12265"},"modified":"2023-02-13T04:19:39","modified_gmt":"2023-02-12T20:19:39","slug":"haeufel-jochen-et-al-published-their-research-in-angewandte-chemie-in-1973-cas-3528-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12265","title":{"rendered":"Haeufel, Jochen et al. published their research in Angewandte Chemie in 1973 | CAS: 3528-58-3"},"content":{"rendered":"<p>Synthesis of 1H-pyrazolo[3,4-b]pyridines was written by Haeufel, Jochen;Breitmaier, Eberhard. And the article was included in Angewandte Chemie in 1973.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 3528-58-3<\/a> This article mentions the following:<\/p>\n<p>The pyrazolopyridines [I; R = Me, Pr, Bu; R1 = H; or RR1 = (CH2)n, n = 4,5,6, or 10; R2 = Me, Et, Ph; R3 = H, Me] were prepared in 51-87% yield by reaction of the pyrazoles II with R1COCR:CHR4 (R4 = OH, alkoxy, NH2) in HOAc and subsequent precipitation with H2O, or addition of NaOH and extraction with Et2O, or distillation of HOAc. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 3528-58-3<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 3528-58-3<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">Recommanded Product: 3528-58-3<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[830,131],"tags":[128],"class_list":["post-12265","post","type-post","status-publish","format-standard","hentry","category-3528-58-3","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Haeufel, Jochen et al. published their research in Angewandte Chemie in 1973 | CAS: 3528-58-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Synthesis of 1H-pyrazolo[3,4-b]pyridines was written by Haeufel, Jochen;Breitmaier, Eberhard. 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