{"id":12255,"date":"2023-02-13T04:17:49","date_gmt":"2023-02-12T20:17:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12255"},"modified":"2023-02-13T04:17:49","modified_gmt":"2023-02-12T20:17:49","slug":"yu-guixue-et-al-published-their-research-in-journal-of-medicinal-chemistry-in-2001-cas-3528-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12255","title":{"rendered":"Yu, Guixue et al. published their research in Journal of Medicinal Chemistry in 2001 | CAS: 3528-58-3"},"content":{"rendered":"<p>Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction was written by Yu, Guixue;Mason, Helen J.;Wu, Ximao;Wang, Jian;Chong, Saeho;Dorough, Gary;Henwood, Andrew;Pongrac, Ronald;Seliger, Laurie;He, Bin;Normandin, Diane;Adam, Leonard;Krupinski, John;Macor, John E.. And the article was included in Journal of Medicinal Chemistry in 2001.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">SDS of cas: 3528-58-3<\/a> This article mentions the following:<\/p>\n<p>Eight potent PDE5 inhibitors represented by <strong>I<\/strong> are described which have a much improved PDE isoenzyme selectivity profile compared to sildenafil. <strong>I<\/strong> was at least equivalent to sildenafil in its functional PDE5 activity in rabbit corpus cavernosal tissue. The pharmacokinetic profile and adverse effects of <strong>I<\/strong> are also briefly discussed. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">SDS of cas: 3528-58-3<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u93ba\u77ef).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">SDS of cas: 3528-58-3<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u93ba\u77ef).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">SDS of cas: 3528-58-3<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[830,131],"tags":[128],"class_list":["post-12255","post","type-post","status-publish","format-standard","hentry","category-3528-58-3","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Yu, Guixue et al. published their research in Journal of Medicinal Chemistry in 2001 | CAS: 3528-58-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction was written by Yu, Guixue;Mason, Helen J.;Wu, Ximao;Wang, Jian;Chong, Saeho;Dorough, Gary;Henwood, Andrew;Pongrac, Ronald;Seliger, Laurie;He, Bin;Normandin, Diane;Adam, Leonard;Krupinski, John;Macor, John E.. 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