{"id":12252,"date":"2023-02-13T04:17:49","date_gmt":"2023-02-12T20:17:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12252"},"modified":"2023-02-13T04:17:49","modified_gmt":"2023-02-12T20:17:49","slug":"bolbut-a-v-et-al-published-their-research-in-zhurnal-organichnoi-ta-farmatsevtichnoi-khimii-in-2006-cas-18213-75-7-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12252","title":{"rendered":"Bol&#8217;but, A. V. et al. published their research in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2006 | CAS: 18213-75-7"},"content":{"rendered":"<p>Condensed pyrimidine systems. 4. Synthesis and transformations of 6-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones was written by Bol&#8217;but, A. V.;Korol&#8217;ov, O. K.;Vovk, M. V.. And the article was included in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2006.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">HPLC of Formula: 18213-75-7<\/a> This article mentions the following:<\/p>\n<p>1-R-6-Trifluoromethyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones (<strong>2a<\/strong>&#8211;<strong>d<\/strong>; R = Me, PhCH<sub>2<\/sub>, Ph, 3-ClC<sub>6<\/sub>H<sub>4<\/sub>) were prepared by heterocyclization of 5-aminopyrazole-4-carboxamides with Me trifluoroacetate. The pyrimidinones <strong>2<\/strong> were converted into the corresponding 4-alkoxy, chloro, amino and hydrazino derivatives and 7-R-5-trifluoromethyl-7<em>H<\/em>-pyrazolo[4,3-e]tetrazolo[1,5-c]pyrimidines (<strong>7a<\/strong>&#8211;<strong>c<\/strong>; R = PhCH<sub>2<\/sub>, Ph, 3-ClC<sub>6<\/sub>H<sub>4<\/sub>). In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">HPLC of Formula: 18213-75-7<\/a>).<\/p>\n<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor\u95b3\u30e6\u5f86onor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">HPLC of Formula: 18213-75-7<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor\u95b3\u30e6\u5f86onor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">HPLC of Formula: 18213-75-7<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[538,131],"tags":[128],"class_list":["post-12252","post","type-post","status-publish","format-standard","hentry","category-18213-75-7","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Bol&#039;but, A. V. et al. published their research in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2006 | CAS: 18213-75-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Condensed pyrimidine systems. 4. Synthesis and transformations of 6-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones was written by Bol&#039;but, A. V.;Korol&#039;ov, O. K.;Vovk, M. V.. And the article was included in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2006.HPLC of Formula: 18213-75-7 This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12252\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bol&#039;but, A. V. et al. published their research in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2006 | CAS: 18213-75-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Condensed pyrimidine systems. 4. Synthesis and transformations of 6-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones was written by Bol&#039;but, A. V.;Korol&#039;ov, O. K.;Vovk, M. V.. 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