{"id":12230,"date":"2023-02-09T10:52:25","date_gmt":"2023-02-09T02:52:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12230"},"modified":"2023-02-09T10:52:25","modified_gmt":"2023-02-09T02:52:25","slug":"das-jagabandhu-et-al-published-their-research-in-bioorganic-medicinal-chemistry-letters-in-2008-cas-55361-49-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12230","title":{"rendered":"Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 55361-49-4"},"content":{"rendered":"<p>Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38\u03b1 inhibitors was written by Das, Jagabandhu;Moquin, Robert V.;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina. And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2008.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Recommanded Product: 1-Ethyl-1H-pyrazol-3-amine<\/a> This article mentions the following:<\/p>\n<p>The synthesis and structure-activity relationships (SAR) of p38\u03b1 MAP kinase inhibitors based on a pyrazolo-pyrimidine scaffold are described. These studies led to the identification of compound <strong>I<\/strong> as a potent and selective inhibitor of p38\u03b1 MAP kinase with excellent cellular potency toward the inhibition of TNF\u03b1 production <strong>I<\/strong> was highly efficacious in vivo in inhibiting TNF\u03b1 production in an acute murine model of TNF\u03b1 production X-ray co-crystallog. of a pyrazolopyrimidine analog bound to unphosphorylated p38\u03b1 is also disclosed. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Recommanded Product: 1-Ethyl-1H-pyrazol-3-amine<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Recommanded Product: 1-Ethyl-1H-pyrazol-3-amine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/55361-49-4.html\">Recommanded Product: 1-Ethyl-1H-pyrazol-3-amine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[832,131],"tags":[128],"class_list":["post-12230","post","type-post","status-publish","format-standard","hentry","category-55361-49-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 55361-49-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38\u03b1 inhibitors was written by Das, Jagabandhu;Moquin, Robert V.;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina. 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And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2008.Recommanded Product: 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=12230","og_locale":"en_US","og_type":"article","og_title":"Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 55361-49-4 | pyrazoles-derivatives","og_description":"Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38\u03b1 inhibitors was written by Das, Jagabandhu;Moquin, Robert V.;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina. And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2008.Recommanded Product: 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12230","og_site_name":"pyrazoles-derivatives","article_published_time":"2023-02-09T02:52:25+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12230","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12230","name":"Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 55361-49-4 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2023-02-09T02:52:25+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38\u03b1 inhibitors was written by Das, Jagabandhu;Moquin, Robert V.;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina. And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2008.Recommanded Product: 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12230#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=12230"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12230#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 55361-49-4"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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