{"id":1223,"date":"2020-12-14T15:41:56","date_gmt":"2020-12-14T07:41:56","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1223"},"modified":"2020-12-14T15:41:56","modified_gmt":"2020-12-14T07:41:56","slug":"application-of-3-cyclopropyl-1-methyl-1h-pyrazol-5-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1223","title":{"rendered":"Application of 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine"},"content":{"rendered":"

118430-74-3<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 118430-74-3 name is 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

A mixture of ferf-butyl 2-(2-(5-bromo-3′-(((tert-butoxycarbonyl)amino)methyl)-5′-fluoro- [1 ,1 ‘-biphenyl]-3-ylcarboxamido)phenyl)acetate (Example 11-B) (100 mg, 0.163 mmol), 3- cyclopropyl-1 -methyl-1 H-pyrazol-5-amine (CAS 118430-74-3) (44.7 mg, 0.326 mmol), Cs2C03 (159 mg, 0.489 mmol) and BrettPhos palladacycle (CAS 1 148148-01-9) (6.51 mg, 8.15 pmol) in CH3CN (2 mL) was heated in a microwave at 160 C for 60 min. The mixture was diluted with EtOAc and water, acidified with 1 N HCI to pH 5. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were concentrated and the residue was purified by HPLC (Method B) to provide the title compound. MS (ESI+) m\/z 670.8 (M+H).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[233,131],"tags":[126],"class_list":["post-1223","post","type-post","status-publish","format-standard","hentry","category-118430-74-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine<\/title>\n<meta name=\"description\" content=\"118430-74-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 118430-74-3 name is 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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