{"id":12221,"date":"2023-02-09T10:51:05","date_gmt":"2023-02-09T02:51:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12221"},"modified":"2023-02-09T10:51:05","modified_gmt":"2023-02-09T02:51:05","slug":"das-jagabandhu-et-al-published-their-research-in-bioorganic-medicinal-chemistry-letters-in-2008-cas-18213-75-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12221","title":{"rendered":"Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 18213-75-7"},"content":{"rendered":"<p>Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38\u03b1 inhibitors was written by Das, Jagabandhu;Moquin, Robert V.;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina. And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2008.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Computed Properties of C5H8N4O<\/a> This article mentions the following:<\/p>\n<p>The synthesis and structure-activity relationships (SAR) of p38\u03b1 MAP kinase inhibitors based on a pyrazolo-pyrimidine scaffold are described. These studies led to the identification of compound <strong>I<\/strong> as a potent and selective inhibitor of p38\u03b1 MAP kinase with excellent cellular potency toward the inhibition of TNF\u03b1 production <strong>I<\/strong> was highly efficacious in vivo in inhibiting TNF\u03b1 production in an acute murine model of TNF\u03b1 production X-ray co-crystallog. of a pyrazolopyrimidine analog bound to unphosphorylated p38\u03b1 is also disclosed. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Computed Properties of C5H8N4O<\/a>).<\/p>\n<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Computed Properties of C5H8N4O<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Computed Properties of C5H8N4O<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[538,131],"tags":[128],"class_list":["post-12221","post","type-post","status-publish","format-standard","hentry","category-18213-75-7","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 18213-75-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38\u03b1 inhibitors was written by Das, Jagabandhu;Moquin, Robert V.;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina. And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2008.Computed Properties of C5H8N4O This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12221\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 18213-75-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38\u03b1 inhibitors was written by Das, Jagabandhu;Moquin, Robert V.;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina. 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And the article was included in Bioorganic &amp; Medicinal Chemistry Letters in 2008.Computed Properties of C5H8N4O This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12221#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=12221"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12221#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Das, Jagabandhu et al. published their research in Bioorganic &amp; Medicinal Chemistry Letters in 2008 | CAS: 18213-75-7"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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