{"id":12198,"date":"2023-02-09T10:49:41","date_gmt":"2023-02-09T02:49:41","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12198"},"modified":"2023-02-09T10:49:41","modified_gmt":"2023-02-09T02:49:41","slug":"liu-yingying-et-al-published-their-research-in-shandong-huagong-in-2018-cas-15953-73-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12198","title":{"rendered":"Liu, Yingying et al. published their research in Shandong Huagong in 2018 | CAS: 15953-73-8"},"content":{"rendered":"<p>Michael addition of \u03b1-nitroacetate to \u03b1, \u03b2-unsaturated pyrazolamide catalyzed by triethylamine was written by Liu, Yingying;He, Qian;Chen, Feng;Li, Xuefeng. And the article was included in Shandong Huagong in 2018.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">Recommanded Product: 15953-73-8<\/a> This article mentions the following:<\/p>\n<p>An efficient Michael addition of \u03b1-nitroacetate to \u03b1, \u03b2-unsaturated pyrazolamide was developed in the presence of triethylamine. Synthetically useful yields (50% \u223c 88%) have been achieved with various \u03b1, \u03b2-unsaturated pyrazolamides. The structures of adducts have been clearly confirmed by <sup>1<\/sup>H-NMR, <sup>13<\/sup>C-NMR and HRMS anal. Adducts resulting from this protocol are useful synthetic intermediates for further synthetic modification. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">Recommanded Product: 15953-73-8<\/a>).<\/p>\n<p>4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">Recommanded Product: 15953-73-8<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">Recommanded Product: 15953-73-8<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[835,131],"tags":[128],"class_list":["post-12198","post","type-post","status-publish","format-standard","hentry","category-15953-73-8","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Liu, Yingying et al. published their research in Shandong Huagong in 2018 | CAS: 15953-73-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Michael addition of \u03b1-nitroacetate to \u03b1, \u03b2-unsaturated pyrazolamide catalyzed by triethylamine was written by Liu, Yingying;He, Qian;Chen, Feng;Li, Xuefeng. 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