{"id":12186,"date":"2023-02-07T02:27:13","date_gmt":"2023-02-06T18:27:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12186"},"modified":"2023-02-07T02:27:13","modified_gmt":"2023-02-06T18:27:13","slug":"ferroni-r-et-al-published-their-research-in-arzneimittel-forschung-in-1990-cas-18213-75-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12186","title":{"rendered":"Ferroni, R. et al. published their research in Arzneimittel-Forschung in 1990 | CAS: 18213-75-7"},"content":{"rendered":"<p>Cyclic guanidines: synthesis and antiplatelet activity of 4,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyrazolo[3,4-d]pyrimidin-7-ones and 1,4,6,7,8,9-hexahydropyrazolo[3&#8242;,4&#8242;:4,5]pyrimido[2,1-c][1,2,4]triazin-7-ones was written by Ferroni, R.;Simoni, D.;Orlandini, P.;Bardi, A.;Franze, G. P.;Guarneri, M.. And the article was included in Arzneimittel-Forschung in 1990.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">SDS of cas: 18213-75-7<\/a> This article mentions the following:<\/p>\n<p><strong>I<\/strong> (R = e.g., Me, Ph, 4-ClC<sub>6<\/sub>H<sub>4<\/sub>, R<sup>1<\/sup> = Bu, benzyl, or H) and <strong>II<\/strong> (R = e.g., Me, Ph, 4-ClC<sub>6<\/sub>H<sub>4<\/sub>) were prepared starting from 5-amino-4-cyano-1-(2,5-dichlorophenyl)pyrazole through a series of reactions. The compounds were tested for inhibition against blood platelet aggregation induced by ADP or collagen. Among the compounds tested <strong>I<\/strong> (R = 2,5-dichlorophenyl, R<sup>1<\/sup> = CH<sub>2<\/sub>Ph), showed the highest activity. An increase in lipophilicity of the substituent was accompanied by an increase in the platelet aggregation inhibitory activity. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">SDS of cas: 18213-75-7<\/a>).<\/p>\n<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">SDS of cas: 18213-75-7<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">SDS of cas: 18213-75-7<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[538,131],"tags":[128],"class_list":["post-12186","post","type-post","status-publish","format-standard","hentry","category-18213-75-7","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ferroni, R. et al. published their research in Arzneimittel-Forschung in 1990 | CAS: 18213-75-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Cyclic guanidines: synthesis and antiplatelet activity of 4,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyrazolo[3,4-d]pyrimidin-7-ones and 1,4,6,7,8,9-hexahydropyrazolo[3&#039;,4&#039;:4,5]pyrimido[2,1-c][1,2,4]triazin-7-ones was written by Ferroni, R.;Simoni, D.;Orlandini, P.;Bardi, A.;Franze, G. P.;Guarneri, M.. And the article was included in Arzneimittel-Forschung in 1990.SDS of cas: 18213-75-7 This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12186\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ferroni, R. et al. published their research in Arzneimittel-Forschung in 1990 | CAS: 18213-75-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Cyclic guanidines: synthesis and antiplatelet activity of 4,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyrazolo[3,4-d]pyrimidin-7-ones and 1,4,6,7,8,9-hexahydropyrazolo[3&#039;,4&#039;:4,5]pyrimido[2,1-c][1,2,4]triazin-7-ones was written by Ferroni, R.;Simoni, D.;Orlandini, P.;Bardi, A.;Franze, G. P.;Guarneri, M.. 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