{"id":12180,"date":"2023-02-07T02:27:13","date_gmt":"2023-02-06T18:27:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12180"},"modified":"2023-02-07T02:27:13","modified_gmt":"2023-02-06T18:27:13","slug":"nitulescu-george-mihai-et-al-published-their-research-in-international-journal-of-molecular-sciences-in-2013-cas-3528-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12180","title":{"rendered":"Nitulescu, George Mihai et al. published their research in International Journal of Molecular Sciences in 2013 | CAS: 3528-58-3"},"content":{"rendered":"<p>New potential antitumor pyrazole derivatives: synthesis and cytotoxic evaluation was written by Nitulescu, George Mihai;Draghici, Constantin;Olaru, Octavian Tudorel. And the article was included in International Journal of Molecular Sciences in 2013.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">HPLC of Formula: 3528-58-3<\/a> This article mentions the following:<\/p>\n<p>New pyrazole derivatives <strong>I<\/strong> (R<sup>1<\/sup> = Cl, CH<sub>3<\/sub>; R<sup>2<\/sup> = H, CH<sub>3<\/sub>; R<sup>3<\/sup> = C<sub>2<\/sub>H<sub>5<\/sub>, C<sub>6<\/sub>H<sub>5<\/sub>; etc.) were designed and synthesized as potential protein kinase inhibitors in the view to develop specific antitumor therapies. The antitumor potential was estimated using wheat seeds and the general toxicity was evaluated by alternative methods, using invertebrate animals. One 3-aminopyrazole derivative <strong>II<\/strong> emerged as a potential candidate for the development of future cytotoxic compounds In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">HPLC of Formula: 3528-58-3<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor\u2013donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">HPLC of Formula: 3528-58-3<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor\u2013donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">HPLC of Formula: 3528-58-3<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[830,131],"tags":[128],"class_list":["post-12180","post","type-post","status-publish","format-standard","hentry","category-3528-58-3","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nitulescu, George Mihai et al. published their research in International Journal of Molecular Sciences in 2013 | CAS: 3528-58-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"New potential antitumor pyrazole derivatives: synthesis and cytotoxic evaluation was written by Nitulescu, George Mihai;Draghici, Constantin;Olaru, Octavian Tudorel. 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