{"id":12176,"date":"2023-02-07T02:27:13","date_gmt":"2023-02-06T18:27:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12176"},"modified":"2023-02-07T02:27:13","modified_gmt":"2023-02-06T18:27:13","slug":"zohdi-hussein-et-al-published-their-research-in-molecules-online-computer-file-in-2001-cas-401-73-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12176","title":{"rendered":"Zohdi, Hussein et al. published their research in Molecules [online computer file] in 2001 | CAS: 401-73-0"},"content":{"rendered":"<p>4-(3-Nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was written by Zohdi, Hussein;Rateb, Nora M.;Haikal, A. Z.. And the article was included in Molecules [online computer file] in 2001.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">COA of Formula: C4H3F3N2O<\/a> This article mentions the following:<\/p>\n<p>4-(3-Nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one (<strong>I<\/strong>) was synthesized by adding 5 mmol of 3-nitrobenzenediazonium chloride dropwise to a cold solution of 5-trifluoromethyl-2,4-dihydropyrazol-3-one (0.76 g, 5 mmol) in 25 mL of ethanol containing sodium acetate (0.82 g, 10 mol). The reaction mixture was stirred at room temperature for 3 h and the precipitated crude product was filtered, washed with water, dried and crystallized from ethanol to give 1.2 g (80%) of <strong>I<\/strong> as orange crystals. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">COA of Formula: C4H3F3N2O<\/a>).<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor\u2013donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">COA of Formula: C4H3F3N2O<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor\u2013donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">COA of Formula: C4H3F3N2O<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[834,131],"tags":[128],"class_list":["post-12176","post","type-post","status-publish","format-standard","hentry","category-401-73-0","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Zohdi, Hussein et al. published their research in Molecules [online computer file] in 2001 | CAS: 401-73-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"4-(3-Nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was written by Zohdi, Hussein;Rateb, Nora M.;Haikal, A. 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