{"id":1217,"date":"2020-12-14T15:41:56","date_gmt":"2020-12-14T07:41:56","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1217"},"modified":"2020-12-14T15:41:56","modified_gmt":"2020-12-14T07:41:56","slug":"extracurricular-laboratory-synthetic-route-of-162758-35-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1217","title":{"rendered":"Extracurricular laboratory: Synthetic route of 162758-35-2"},"content":{"rendered":"

A common compound: 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 162758-35-2<\/a><\/p>\n

To a solution of the compound NDS-100226 (76 mg, 0.20 mmol)in dry dichloromethane, was added N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (EDC.HC1, 40 mg, 0.26 mmol), Hydroxybenzotriazole (HOBt, 35 mg, 0.26 mmol) and diisopropylethyl amine (0.1 mL, 0.60 mmol) at 0C. Then the amine 3 was added and stirred at RT for 6 h. To the reaction mixture water was added and the organic layer was separated, washed with saturated NaHC03, IN HQ, dried over Na2S04 and concentrated under reduced pressure. This crude mixture was purified by column chromatography to give the title compound NDS-100240 (90 mg) as a white fluffy solid in 89% yield. NMR (400 MHz, CDQ3): delta 7.44 (d, J = 1.8 Hz, 1H), 7.32-7.29 (m, 4H), 7.06 (d, J = 8.3 Hz, 2H), 3.21 (t, J = 6.0 Hz, 411), 2.37 (s, 3H), 0.97 (t, J = 6.3 Hz, 4H), 0.10 (s, 6H) ); 13C NMR (100 MHz, CDC13): 6 159.9, 144.4, 142.9, 135.9 (2C), 134.9, 132.9, 130.8 (2C), 130.5, 130.3, 128.9 (2C), 127.8, 127.2, 1 18.2, 55.4, 13.2, 9.3, -3.5 (2C).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 162758-35-2, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 162758-35-2, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,131],"tags":[167],"class_list":["post-1217","post","type-post","status-publish","format-standard","hentry","category-162758-35-2","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of 162758-35-2<\/title>\n<meta name=\"description\" content=\"A common compound: 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. 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