{"id":12161,"date":"2023-02-03T04:14:56","date_gmt":"2023-02-02T20:14:56","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12161"},"modified":"2023-02-03T04:14:56","modified_gmt":"2023-02-02T20:14:56","slug":"elguero-jose-et-al-published-their-research-in-bulletin-de-la-societe-chimique-de-france-in-1974-cas-934-48-5-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12161","title":{"rendered":"Elguero, Jose et al. published their research in Bulletin de la Societe Chimique de France in 1974 | CAS: 934-48-5"},"content":{"rendered":"<p>NMR studies in heterocyclic series. XIV. Phenomena of restricted rotation observed in N  COR derivatives of azoles and 2-pyrazolines was written by Elguero, Jose;Marzin, Claude;Pappalardo, Louis. And the article was included in Bulletin de la Societe Chimique de France in 1974.<a href=\"https:\/\/www.ambeed.com\/products\/934-48-5.html\">SDS of cas: 934-48-5<\/a> This article mentions the following:<\/p>\n<p>NMR data were obtained for all the 1-acetyl-monosubstituted 5-membered N heterocycles (pyrrole through tetrazole), for pyrazoles I (R, R1, R2, and X given: MeO, H, H, O; MeO, Me, Me, O; NH2, H, H, O; NH2, Me, Me, O; NH2, Me, Me, NH; NH2, Me, Me, NH2+), and for 2-pyrazolines II (R = Me, MeO, NH2, NMe2; R1 = R3 = Me, R2 = H; R = MeO, NMe2, R1 = Me2CH, R2 = Me, R3 = H). Rotational barriers were calculated for I (R = MeO, R1 = R2 = H, X = O; R = NH2, R1 = R2 = H, Me, X = O) and for II (R = MeO, R1 = Me2CH, R2 = Me, R3 = H; R = NH2, R1 = R3 = Me, R2 = H). Solvent effects on NMR were shown and the inability to calculate rotational barriers for the 1-acetyl compounds and the hindered rotation of the 1-carbamoyl compounds were discussed. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5<a href=\"https:\/\/www.ambeed.com\/products\/934-48-5.html\">SDS of cas: 934-48-5<\/a>).<\/p>\n<p>3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/934-48-5.html\">SDS of cas: 934-48-5<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.<a href=\"https:\/\/www.ambeed.com\/products\/934-48-5.html\">SDS of cas: 934-48-5<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-12161","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Elguero, Jose et al. published their research in Bulletin de la Societe Chimique de France in 1974 | CAS: 934-48-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"NMR studies in heterocyclic series. XIV. Phenomena of restricted rotation observed in N COR derivatives of azoles and 2-pyrazolines was written by Elguero, Jose;Marzin, Claude;Pappalardo, Louis. And the article was included in Bulletin de la Societe Chimique de France in 1974.SDS of cas: 934-48-5 This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12161\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Elguero, Jose et al. published their research in Bulletin de la Societe Chimique de France in 1974 | CAS: 934-48-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"NMR studies in heterocyclic series. XIV. Phenomena of restricted rotation observed in N COR derivatives of azoles and 2-pyrazolines was written by Elguero, Jose;Marzin, Claude;Pappalardo, Louis. And the article was included in Bulletin de la Societe Chimique de France in 1974.SDS of cas: 934-48-5 This article mentions the following:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12161\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2023-02-02T20:14:56+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12161\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12161\",\"name\":\"Elguero, Jose et al. published their research in Bulletin de la Societe Chimique de France in 1974 | CAS: 934-48-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2023-02-02T20:14:56+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"NMR studies in heterocyclic series. XIV. Phenomena of restricted rotation observed in N COR derivatives of azoles and 2-pyrazolines was written by Elguero, Jose;Marzin, Claude;Pappalardo, Louis. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Elguero, Jose et al. published their research in Bulletin de la Societe Chimique de France in 1974 | CAS: 934-48-5 | pyrazoles-derivatives","description":"NMR studies in heterocyclic series. 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