{"id":12157,"date":"2023-02-03T04:14:56","date_gmt":"2023-02-02T20:14:56","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12157"},"modified":"2023-02-03T04:14:56","modified_gmt":"2023-02-02T20:14:56","slug":"wieting-joshua-m-et-al-published-their-research-in-acs-chemical-neuroscience-in-2017-cas-141459-53-2-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12157","title":{"rendered":"Wieting, Joshua M. et al. published their research in ACS Chemical Neuroscience in 2017 | CAS: 141459-53-2"},"content":{"rendered":"<p>Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1\/2 Potassium Channel Activators was written by Wieting, Joshua M.;Vadukoot, Anish K.;Sharma, Swagat;Abney, Kristopher K.;Bridges, Thomas M.;Daniels, J. Scott;Morrison, Ryan D.;Wickman, Kevin;Weaver, C. David;Hopkins, Corey R.. And the article was included in ACS Chemical Neuroscience in 2017.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">SDS of cas: 141459-53-2<\/a> This article mentions the following:<\/p>\n<p>The G protein-gated inwardly-rectifying potassium channels (GIRK, K<sub>ir<\/sub>3) are a family of inward-rectifying potassium channels, and there is significant evidence supporting the roles of GIRKs in a number of physiol. processes and as potential targets for numerous indications. Previously reported urea containing mols. as GIRK1\/2 preferring activators have had significant pharmacokinetic (PK) liabilities. Here we report a novel series of 1H-pyrazolo-5-yl-2-phenylacetamides in an effort to improve upon the PK properties. This series of compounds display nanomolar potency as GIRK1\/2 activators with improved brain distribution (rodent K<sub>p<\/sub> &gt; 0.6). In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">SDS of cas: 141459-53-2<\/a>).<\/p>\n<p>1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">SDS of cas: 141459-53-2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">SDS of cas: 141459-53-2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-12157","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Wieting, Joshua M. et al. published their research in ACS Chemical Neuroscience in 2017 | CAS: 141459-53-2 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1\/2 Potassium Channel Activators was written by Wieting, Joshua M.;Vadukoot, Anish K.;Sharma, Swagat;Abney, Kristopher K.;Bridges, Thomas M.;Daniels, J. Scott;Morrison, Ryan D.;Wickman, Kevin;Weaver, C. David;Hopkins, Corey R.. And the article was included in ACS Chemical Neuroscience in 2017.SDS of cas: 141459-53-2 This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12157\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wieting, Joshua M. et al. published their research in ACS Chemical Neuroscience in 2017 | CAS: 141459-53-2 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1\/2 Potassium Channel Activators was written by Wieting, Joshua M.;Vadukoot, Anish K.;Sharma, Swagat;Abney, Kristopher K.;Bridges, Thomas M.;Daniels, J. 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And the article was included in ACS Chemical Neuroscience in 2017.SDS of cas: 141459-53-2 This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12157","og_site_name":"pyrazoles-derivatives","article_published_time":"2023-02-02T20:14:56+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12157","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12157","name":"Wieting, Joshua M. et al. published their research in ACS Chemical Neuroscience in 2017 | CAS: 141459-53-2 | pyrazoles-derivatives","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2023-02-02T20:14:56+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1\/2 Potassium Channel Activators was written by Wieting, Joshua M.;Vadukoot, Anish K.;Sharma, Swagat;Abney, Kristopher K.;Bridges, Thomas M.;Daniels, J. 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And the article was included in ACS Chemical Neuroscience in 2017.SDS of cas: 141459-53-2 This article mentions the following:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12157#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=12157"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12157#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Wieting, Joshua M. et al. published their research in ACS Chemical Neuroscience in 2017 | CAS: 141459-53-2"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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