{"id":1214,"date":"2020-12-14T15:41:56","date_gmt":"2020-12-14T07:41:56","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1214"},"modified":"2020-12-14T15:41:56","modified_gmt":"2020-12-14T07:41:56","slug":"new-downstream-synthetic-route-of-ethyl-3-trifluoromethylpyrazole-4-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1214","title":{"rendered":"New downstream synthetic route of Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate"},"content":{"rendered":"

155377-19-8<\/a>, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below.<\/p>\n

Example 12 Ethyl 1-(5-iodo-2-isopropylthio-6-trifluororethylpyrimidin-4-yl)-3-trifluoromethyl-1H-pyrazol-4-carboxylate 4-Chloro-5-iodo-2-isopropylthio-6-trifluoromethylpyrimidine (0.30 g) was dissolved in dimethylsulfoxide (3.0 ml) and ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate (0.16 g) and 1,8-diazabicyclo-[5,4,0]-under-7-ene (0.12 g) was added at room temperature with stirring. The mixture was heated to 80 C. and stirred for 2 hr. After cooling to room temperature, the mixture was added water and extracted with benzene. The benzene layer was washed with water and brine, respectively and dried over magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give ethyl 1-(5-iodo-2-isopropylthio-6-trifluoromethylpyrimidin-4-yl)-3-trifluoromethyl-1H-pyrazole-4-carboxylate (0.30 g) as colorless crystalline solid, mp 107-108 C.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[226,131],"tags":[127],"class_list":["post-1214","post","type-post","status-publish","format-standard","hentry","category-155377-19-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nNew downstream synthetic route of Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate<\/title>\n<meta name=\"description\" content=\"155377-19-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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