{"id":1211,"date":"2020-12-11T17:31:53","date_gmt":"2020-12-11T09:31:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1211"},"modified":"2020-12-11T17:31:53","modified_gmt":"2020-12-11T09:31:53","slug":"sources-of-common-compounds-288148-34-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1211","title":{"rendered":"Sources of common compounds: 288148-34-5"},"content":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life. 288148-34-5<\/a><\/p>\n

General procedure: A mixture of the appropriate (aryloxy)ethyl piperidine(0.38 mmol) in CH2Cl2 (3 mL), and TEA (1.14 mmol) was cooled down (ice bath), and arylsulfonyl chloride (0.46 mmol) was added at 0 C in one portion. The reaction mixture was stirred for 2-6 h under cooling. Then, the solvent was evaporated and the sulfonamides were purified using silica gel column with CH2Cl2\/MeOH as an eluting system. Free bases were then converted into the hydrochloride salts by treatment of their solution in anhydrous ethanol with 1.25 M HCl in MeOH.; 9.2.6.18 1-Methyl-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}-N-cyclopropylmethyl-1H-pyrazole-4-sulfonamide (33) Yellow oil, 70 mg following chromatographic purification over silica gel with CH2Cl2\/MeOH (9:0.7); LC\/MS purity 100%, tR = 5.37, C27H34N4O3S, MW 494.65, Monoisotopic Mass 494.24, [M+H]+ 495.4 1H NMR (300 MHz, CDCl3) delta 0.25-0.31 (m, 2H), 0.47-0.55 (m, 2H), 1.52-1.58 (m, 2H), 2.32-2.59 (m, 4H), 3.00 (d, J = 6.73 Hz, 2H), 3.22-3.37 (m, 4H), 3.66-3.76 (m, 2H), 3.92 (s, 3H), 4.37-4.41 (m, 2H), 6.93 (d, J = 8.17 Hz, 1H), 7.02 -7.09 (m, 1H), 7.22-7.38 (m, 7H), 7.65 (s, 1H), 7.78 (s, 1H). 13C NMR (75 MHz, CDCl3) delta 5.16, 12.14, 27.56, 39.52, 48.23, 52.22, 52.73, 52.76, 52.79, 55.72, 63.25, 112.65, 122.28, 123.23, 127.20, 128.00, 128.99, 129.55, 130.81, 131.41, 131.59, 137.84, 138.35, 154.12. Anal. calcd for C27H34N4O3S\u00a1\u00a42HCl: C, 57.14; H, 6.39; N, 9.87; S, 5.65; Found: C, 56.94; H, 6.69′ N, 10.12; S, 5.36. Mp for C27H34N4O3S\u00a1\u00a42HCl: 198.3-198.8 C.<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 288148-34-5. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 288148-34-5. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[224,131],"tags":[126],"class_list":["post-1211","post","type-post","status-publish","format-standard","hentry","category-288148-34-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds: 288148-34-5<\/title>\n<meta name=\"description\" content=\"The chemical industry reduces the impact on the environment during synthesis 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life. 288148-34-5\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1211\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds: 288148-34-5\" \/>\n<meta property=\"og:description\" content=\"The chemical industry reduces the impact on the environment during synthesis 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life. 288148-34-5\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1211\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-11T09:31:53+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1211\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1211\",\"name\":\"Sources of common compounds: 288148-34-5\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-12-11T09:31:53+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"The chemical industry reduces the impact on the environment during synthesis 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life. 288148-34-5\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1211#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=1211\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1211#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sources of common compounds: 288148-34-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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