{"id":12092,"date":"2023-01-30T07:04:01","date_gmt":"2023-01-29T23:04:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12092"},"modified":"2023-01-30T07:04:01","modified_gmt":"2023-01-29T23:04:01","slug":"vicentini-chiara-b-et-al-published-their-research-in-heterocycles-in-1993-cas-141459-53-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12092","title":{"rendered":"Vicentini, Chiara B. et al. published their research in Heterocycles in 1993 | CAS: 141459-53-2"},"content":{"rendered":"<p>An efficient procedure for the synthesis of pyrazolo[3,4-d][1,3]thiazin-4-ones was written by Vicentini, Chiara B.;Veronese, Augusto C.;Guccione, Salvatore;Guarneri, Mario;Manfrini, Maurizio;Giori, Paolo. And the article was included in Heterocycles in 1993.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">Computed Properties of C8H15N3<\/a> This article mentions the following:<\/p>\n<p>Trichloromethyl chloroformate reacts with N-(1-alkyl\/aryl-5-pyrazolyl) thiocarboxamides to give pyrazolo[3,4-d][1,3]thiazin-4-ones <strong>I<\/strong> (R<sup>1<\/sup>-R<sup>2<\/sup> = alkyl, etc.) while it reacts with N-(3-methyl-5-pyrazolyl)thiobenzamide to give the pyrazolo[1,5-c][1,3,5]thiadiazine-4-one (<strong>II<\/strong>). Heating under reflux in formic acid of <strong>I<\/strong> homologs bearing a tert-Bu group linked to pyrazole N-1 atom afforded dealkylated derivatives of <strong>I<\/strong>. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">Computed Properties of C8H15N3<\/a>).<\/p>\n<p>1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">Computed Properties of C8H15N3<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/141459-53-2.html\">Computed Properties of C8H15N3<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-12092","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vicentini, Chiara B. et al. published their research in Heterocycles in 1993 | CAS: 141459-53-2 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"An efficient procedure for the synthesis of pyrazolo[3,4-d][1,3]thiazin-4-ones was written by Vicentini, Chiara B.;Veronese, Augusto C.;Guccione, Salvatore;Guarneri, Mario;Manfrini, Maurizio;Giori, Paolo. And the article was included in Heterocycles in 1993.Computed Properties of C8H15N3 This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12092\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vicentini, Chiara B. et al. published their research in Heterocycles in 1993 | CAS: 141459-53-2 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"An efficient procedure for the synthesis of pyrazolo[3,4-d][1,3]thiazin-4-ones was written by Vicentini, Chiara B.;Veronese, Augusto C.;Guccione, Salvatore;Guarneri, Mario;Manfrini, Maurizio;Giori, Paolo. 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And the article was included in Heterocycles in 1993.Computed Properties of C8H15N3 This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12092","og_site_name":"pyrazoles-derivatives","article_published_time":"2023-01-29T23:04:01+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12092","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12092","name":"Vicentini, Chiara B. et al. published their research in Heterocycles in 1993 | CAS: 141459-53-2 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2023-01-29T23:04:01+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"An efficient procedure for the synthesis of pyrazolo[3,4-d][1,3]thiazin-4-ones was written by Vicentini, Chiara B.;Veronese, Augusto C.;Guccione, Salvatore;Guarneri, Mario;Manfrini, Maurizio;Giori, Paolo. 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