{"id":12082,"date":"2023-01-30T07:02:31","date_gmt":"2023-01-29T23:02:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12082"},"modified":"2023-01-30T07:02:31","modified_gmt":"2023-01-29T23:02:31","slug":"shestopalov-a-m-et-al-published-their-research-in-chemistry-of-heterocyclic-compounds-in-2002-cas-401-73-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12082","title":{"rendered":"Shestopalov, A. M. et al. published their research in Chemistry of Heterocyclic Compounds in 2002 | CAS: 401-73-0"},"content":{"rendered":"<p>Synthesis of substituted 6-amino-4-aryl-5-cyano-2H,4H-pyrano[2,3-c]pyrazoles. Crystal and molecular structure of 6-amino-5-cyano-3-methyl-4-(2&#8242;,4&#8242;,6&#8242;-triethylphenyl)-2H,4H-pyrano[2,3-c]pyrazole was written by Shestopalov, A. M.;Yakubov, A. P.;Tsyganov, D. V.;Emel&#8217;yanova, Yu. M.;Nesterov, V. N.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2002.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Synthetic Route of C4H3F3N2O<\/a> This article mentions the following:<\/p>\n<p>Substituted 6-aminopyrano[2,3-c]pyrazoles <strong>I<\/strong> [R = Me, Et, n-Pr, tert-Bu, Ph, CF<sub>3<\/sub>, MeOCH<sub>2<\/sub>, MeOCOCH<sub>2<\/sub>, 4-MeC<sub>6<\/sub>H<sub>4<\/sub>SCH<sub>2<\/sub>; R<sup>1<\/sup> = 2,4,6-Me<sub>3<\/sub>C<sub>6<\/sub>H<sub>2<\/sub>, 2,4,6-Me<sub>3<\/sub>-3-O<sub>2<\/sub>NC<sub>6<\/sub>H, 2,4,6-Me<sub>3<\/sub>-3,5-(O<sub>2<\/sub>N)<sub>2<\/sub>C<sub>6<\/sub>, 2,4,6-Me<sub>3<\/sub>-3-(EtOCH<sub>2<\/sub>)C<sub>6<\/sub>H, 2,4,6-Et<sub>3<\/sub>C<sub>6<\/sub>H<sub>2<\/sub>, 2,5-(MeO)<sub>2<\/sub>C<sub>6<\/sub>H<sub>3<\/sub>, 2,3,4-, 2,4,5-(MeO)<sub>3<\/sub>C<sub>6<\/sub>H<sub>2<\/sub>, 2-F<sub>3<\/sub>C-, 2-MeC<sub>6<\/sub>H<sub>4<\/sub>, 2-(2-ClC<sub>6<\/sub>H<sub>4<\/sub>CH<sub>2<\/sub>O)C<sub>6<\/sub>H<sub>4<\/sub>, 2-thienyl, 2-furanyl, 3-pyridinyl] were synthesized by the two-component condensation of arylidenemalononitriles, R<sup>1<\/sup>CH:C(CN)<sub>2<\/sub>, and pyrazolones <strong>II<\/strong> or by the three-component condensation of aromatic aldehydes, R<sup>1<\/sup>CHO, malononitrile, and pyrazolones <strong>II<\/strong>. It was established by X-ray crystallog. anal. that pyranopyrazoles exist in the 2H and not the 1H tautomeric form. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Synthetic Route of C4H3F3N2O<\/a>).<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Synthetic Route of C4H3F3N2O<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Synthetic Route of C4H3F3N2O<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-12082","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Shestopalov, A. M. et al. published their research in Chemistry of Heterocyclic Compounds in 2002 | CAS: 401-73-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Synthesis of substituted 6-amino-4-aryl-5-cyano-2H,4H-pyrano[2,3-c]pyrazoles. Crystal and molecular structure of 6-amino-5-cyano-3-methyl-4-(2&#039;,4&#039;,6&#039;-triethylphenyl)-2H,4H-pyrano[2,3-c]pyrazole was written by Shestopalov, A. M.;Yakubov, A. P.;Tsyganov, D. V.;Emel&#039;yanova, Yu. M.;Nesterov, V. N.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2002.Synthetic Route of C4H3F3N2O This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12082\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Shestopalov, A. M. et al. published their research in Chemistry of Heterocyclic Compounds in 2002 | CAS: 401-73-0 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Synthesis of substituted 6-amino-4-aryl-5-cyano-2H,4H-pyrano[2,3-c]pyrazoles. Crystal and molecular structure of 6-amino-5-cyano-3-methyl-4-(2&#039;,4&#039;,6&#039;-triethylphenyl)-2H,4H-pyrano[2,3-c]pyrazole was written by Shestopalov, A. M.;Yakubov, A. P.;Tsyganov, D. V.;Emel&#039;yanova, Yu. M.;Nesterov, V. N.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2002.Synthetic Route of C4H3F3N2O This article mentions the following:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12082\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-29T23:02:31+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12082\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12082\",\"name\":\"Shestopalov, A. M. et al. published their research in Chemistry of Heterocyclic Compounds in 2002 | CAS: 401-73-0 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2023-01-29T23:02:31+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthesis of substituted 6-amino-4-aryl-5-cyano-2H,4H-pyrano[2,3-c]pyrazoles. Crystal and molecular structure of 6-amino-5-cyano-3-methyl-4-(2',4',6'-triethylphenyl)-2H,4H-pyrano[2,3-c]pyrazole was written by Shestopalov, A. M.;Yakubov, A. P.;Tsyganov, D. V.;Emel'yanova, Yu. M.;Nesterov, V. N.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2002.Synthetic Route of C4H3F3N2O This article mentions the following:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12082#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=12082\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=12082#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shestopalov, A. 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And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2002.Synthetic Route of C4H3F3N2O This article mentions the following:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12082","og_site_name":"pyrazoles-derivatives","article_published_time":"2023-01-29T23:02:31+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=12082","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=12082","name":"Shestopalov, A. 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