{"id":12081,"date":"2023-01-30T07:02:31","date_gmt":"2023-01-29T23:02:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12081"},"modified":"2023-01-30T07:02:31","modified_gmt":"2023-01-29T23:02:31","slug":"palysaeva-nadezhda-v-et-al-published-their-research-in-organic-chemistry-frontiers-in-2019-cas-5334-39-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12081","title":{"rendered":"Palysaeva, Nadezhda V. et al. published their research in Organic Chemistry Frontiers in 2019 | CAS: 5334-39-4"},"content":{"rendered":"<p>N-(2-Fluoro-2,2-dinitroethyl)azoles: a novel assembly of diverse explosophoric building blocks for energetic compound design was written by Palysaeva, Nadezhda V.;Gladyshkin, Aleksei G.;Vatsadze, Irina A.;Suponitsky, Kyrill Yu.;Dmitriev, Dmitry E.;Sheremetev, Aleksei B.. And the article was included in Organic Chemistry Frontiers in 2019.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Recommanded Product: 5334-39-4<\/a> This article mentions the following:<\/p>\n<p>The first simple two-step protocol to efficiently prepare unprecedented N-(2-fluoro-2,2,-dinitroethyl) derivatives of imidazoles, pyrazoles, triazoles and tetrazoles e.g., <strong>I<\/strong>. Michael addition of NH-azoles to 1,1-dinitroethene, generated from 1,1,1-trinitroethane, followed by fluorination provided the N-dinitrofluoroethylated nitrogen heterocycles in moderate to good overall yields. The synthesis employed azoles with electron-withdrawing groups, predominantly the nitro group and could be extended to other structurally attractive electron-deficient NH-heterocycles. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Recommanded Product: 5334-39-4<\/a>).<\/p>\n<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Recommanded Product: 5334-39-4<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Recommanded Product: 5334-39-4<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-12081","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Palysaeva, Nadezhda V. et al. published their research in Organic Chemistry Frontiers in 2019 | CAS: 5334-39-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"N-(2-Fluoro-2,2-dinitroethyl)azoles: a novel assembly of diverse explosophoric building blocks for energetic compound design was written by Palysaeva, Nadezhda V.;Gladyshkin, Aleksei G.;Vatsadze, Irina A.;Suponitsky, Kyrill Yu.;Dmitriev, Dmitry E.;Sheremetev, Aleksei B.. 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