{"id":1208,"date":"2020-12-11T17:31:53","date_gmt":"2020-12-11T09:31:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1208"},"modified":"2020-12-11T17:31:53","modified_gmt":"2020-12-11T09:31:53","slug":"simple-exploration-of-27069-17-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1208","title":{"rendered":"Simple exploration of 27069-17-6"},"content":{"rendered":"

27069-17-6<\/a>, Name is 3-(4-Methoxyphenyl)-1H-pyrazole, 27069-17-6, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.<\/p>\n

PREPARATION OF EXAMPLE 17 1-(4-Benzoylpiperazin-1-yl)-2-(4-(3-(4-methoxyphenyl)-1H-pyrazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)ethane-1,2-dione (Compound 25) EAXMAPLE 17 In a sealed tube dicarbonyl intermediate 10 (50 mg, 0.13 mmol), 3-(4-methoxyphenyl)-1H-pyrazole (105 mg, 0.60 mmol) and 1,4-dioxane (2.5 mL) were combined and heated at 170 C. with microwaves for 20 min. The reaction was concentrated and triturated with MeOH (3 mL). The resulting solids were washed with MeOH and with Et2O to yield 25 (43 mg, 0.08 mmol, 61%) as a tan solid. 1H NMR: (500 MHz, DMSO-d6) delta 12.41 (br s, 1H), 8.91 (d, J=2.8 Hz, 1H), 8.89 (s, 1H), 8.55 (br d, J=3.4 Hz, 1H), 8.20 (d, J=8.7 Hz, 2H), 7.51-7.39 (m, 5H), 7.23 (d, J=2.8 Hz, 1H), 7.08 (d, J=8.7 Hz, 2H), 3.85 (s, 3H), 3.92-3.21 (m, 8H); LC\/MS: (ES+) m\/z (M+H)+=535; HPLC Rt=1.40 min., column Q, conditions B.<\/p>\n

Statistics shows that 3-(4-Methoxyphenyl)-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 27069-17-6.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 3-(4-Methoxyphenyl)-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 27069-17-6.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[221,131],"tags":[126],"class_list":["post-1208","post","type-post","status-publish","format-standard","hentry","category-27069-17-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 27069-17-6<\/title>\n<meta name=\"description\" content=\"27069-17-6, Name is 3-(4-Methoxyphenyl)-1H-pyrazole, 27069-17-6, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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