{"id":12077,"date":"2023-01-30T07:02:31","date_gmt":"2023-01-29T23:02:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12077"},"modified":"2023-01-30T07:02:31","modified_gmt":"2023-01-29T23:02:31","slug":"grandberg-i-i-et-al-published-their-research-in-vestnik-moskovskogo-universiteta-seriya-6-biologiya-pochvovedenie-in-1961-cas-5334-39-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12077","title":{"rendered":"Grandberg, I. I. et al. published their research in Vestnik Moskovskogo Universiteta, Seriya 6:  Biologiya, Pochvovedenie in 1961 | CAS: 5334-39-4"},"content":{"rendered":"<p>Pyrazoles. XXI. Biological activity of pyrazole derivatives was written by Grandberg, I. I.;Milovanova, S. N.;Kost, A. N.;Nette, I. T.. And the article was included in Vestnik Moskovskogo Universiteta, Seriya 6:  Biologiya, Pochvovedenie in 1961.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Electric Literature of C4H5N3O2<\/a> This article mentions the following:<\/p>\n<p>Ninety-six pyrazole (I) derivatives were tested by the paperdisk method for their effect on the growth of various bacterial cultures. A majority of the compounds tested were in effective; only those derivatives containing Hg were effective. 3,5-Dimethyl-4-nitropyrazole, m. 126\u00b0; 3,5-dimethyl-4aminopyrazole, m. 204-5\u00b0; 4-nitro-3-methylpyrazole, m. 134\u00b0; 4-amino-3(5)-methylpyrazole, m. 90\u00b0; 3,5-dimethyl4-thiocyanatopyrazole, m. 209\u00b0; 3,5-dimethylpyrazole-4sulfonyl chloride, m. 98\u00b0; 3,5-dimethyl-4-chloropyrazole, m. 117\u00b0; 3,5-dimethyl-4-chloro-1-pyrazolylsuccinic acid, m. 191\u00b0; and 3,5-dimethyl-4-nitro-1-pyrazolylsuccinic acid, m. 189\u00b0 were prepared In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Electric Literature of C4H5N3O2<\/a>).<\/p>\n<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor\u2013donor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Electric Literature of C4H5N3O2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor\u2013donor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Electric Literature of C4H5N3O2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-12077","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Grandberg, I. I. et al. published their research in Vestnik Moskovskogo Universiteta, Seriya 6: Biologiya, Pochvovedenie in 1961 | CAS: 5334-39-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazoles. XXI. Biological activity of pyrazole derivatives was written by Grandberg, I. 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