{"id":12047,"date":"2023-01-06T03:44:51","date_gmt":"2023-01-05T19:44:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12047"},"modified":"2023-01-06T03:44:51","modified_gmt":"2023-01-05T19:44:51","slug":"gomez-guillen-manuel-et-al-published-their-research-in-carbohydrate-research-in-1989-cas-10199-53-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12047","title":{"rendered":"Gomez-Guillen, Manuel et al. published their research in Carbohydrate Research in 1989 | CAS: 10199-53-8"},"content":{"rendered":"<p>New pentahydroxypentylpyrazoles from the reactions of <smallcap>D<\/smallcap>-mannose and <smallcap>D<\/smallcap>-galactose methylhydrazones with nitroalkenes was written by Gomez-Guillen, Manuel;Hans-Hans, Felisa;Lassaletta Simon, Jose Maria;Martin-Zamora, Maria Eloisa. And the article was included in Carbohydrate Research in 1989.<a href=\"https:\/\/www.ambeed.com\/products\/10199-53-8.html\">Application In Synthesis of 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid<\/a> This article mentions the following:<\/p>\n<p>Reaction of methylhydrazones <strong>I<\/strong> (R = OH, R<sup>1<\/sup> = H; R = H, R<sup>1<\/sup> = OH) with nitroalkenes O<sub>2<\/sub>NCR<sup>2<\/sup>:CHR<sup>3<\/sup> (R<sup>2<\/sup> = H, Me, R<sup>3<\/sup> = Ph; R<sup>2<\/sup> = H, Me, R<sup>3<\/sup> = <em>p<\/em>-tolyl) in DMF-H<sub>2<\/sub>O gave 50-75% the corresponding pyrazoles <strong>II<\/strong>. Structures of <strong>II<\/strong> were confirmed by <em>O<\/em>-acetylation, oxidation of the side-chain to CHO or CO<sub>2<\/sub>H groups, and UV and NMR spectral studies. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8<a href=\"https:\/\/www.ambeed.com\/products\/10199-53-8.html\">Application In Synthesis of 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid<\/a>).<\/p>\n<p>1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/10199-53-8.html\">Application In Synthesis of 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/10199-53-8.html\">Application In Synthesis of 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[129],"class_list":["post-12047","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gomez-Guillen, Manuel et al. published their research in Carbohydrate Research in 1989 | CAS: 10199-53-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"New pentahydroxypentylpyrazoles from the reactions of D-mannose and D-galactose methylhydrazones with nitroalkenes was written by Gomez-Guillen, Manuel;Hans-Hans, Felisa;Lassaletta Simon, Jose Maria;Martin-Zamora, Maria Eloisa. 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