{"id":12044,"date":"2023-01-06T03:44:51","date_gmt":"2023-01-05T19:44:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12044"},"modified":"2023-01-06T03:44:51","modified_gmt":"2023-01-05T19:44:51","slug":"shamala-devadas-et-al-published-their-research-in-journal-of-chemical-sciences-berlin-germany-in-2019-cas-3528-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12044","title":{"rendered":"Shamala, Devadas et al. published their research in Journal of Chemical Sciences (Berlin, Germany) in 2019 | CAS: 3528-58-3"},"content":{"rendered":"<p>Zinc chloride catalyzed multicomponent synthesis of pyrazolopyridocoumarin scaffolds was written by Shamala, Devadas;Shivashankar, Kalegowda;Chandra;Mahendra, Madegowda. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2019.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">COA of Formula: C5H9N3<\/a> This article mentions the following:<\/p>\n<p>An efficient synthesis of a series of pyrazolopyridocoumarins <strong>I<\/strong> (R<sup>1<\/sup> = Ph, 4-bromophenyl, 2,3-dimethoxyphenyl, etc.; R<sup>2<\/sup> = Et, Me) is reported by condensation of 4-hydroxycoumarin, benzaldehydes R<sup>1<\/sup>CHO and 1-alkyl-5-amino-pyrazoles <strong>II<\/strong> in the presence of 10 mol% zinc chloride in ethanol under reflux conditions through one-pot reaction. The significant attraction of this protocol is being a simple procedure, mild reaction condition, and excellent yield. The mol. structure of the compound <strong>I<\/strong> (R<sup>1<\/sup> = 2,3-dimethoxyphenyl; R<sup>2<\/sup> = Et) is established by single crystal X-ray structure determination In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">COA of Formula: C5H9N3<\/a>).<\/p>\n<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">COA of Formula: C5H9N3<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.<a href=\"https:\/\/www.ambeed.com\/products\/3528-58-3.html\">COA of Formula: C5H9N3<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-12044","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Shamala, Devadas et al. published their research in Journal of Chemical Sciences (Berlin, Germany) in 2019 | CAS: 3528-58-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Zinc chloride catalyzed multicomponent synthesis of pyrazolopyridocoumarin scaffolds was written by Shamala, Devadas;Shivashankar, Kalegowda;Chandra;Mahendra, Madegowda. 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