{"id":12010,"date":"2023-01-05T03:46:11","date_gmt":"2023-01-04T19:46:11","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=12010"},"modified":"2023-01-05T03:46:11","modified_gmt":"2023-01-04T19:46:11","slug":"laikhter-a-l-et-al-published-their-research-in-izvestiya-akademii-nauk-sssr-seriya-khimicheskaya-in-1991-cas-5334-39-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=12010","title":{"rendered":"Laikhter, A. L. et al. published their research in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1991 | CAS: 5334-39-4"},"content":{"rendered":"<p>gem-Dinitro compounds in organic synthesis.  2.  Synthesis of 4-nitropyrazoles from dinitromethane and its derivatives was written by Laikhter, A. L.;Cherkasova, T. I.;Semenov, V. V.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1991.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">SDS of cas: 5334-39-4<\/a> This article mentions the following:<\/p>\n<p>Treating azines RCH:NN:CHR (R = Me, Pr) with the Na salt of CH<sub>2<\/sub>(NO<sub>2<\/sub>)<sub>2<\/sub> in MeCN gave 27 and 21% nitropyrazoles <strong>I<\/strong>. Treating RCH:NN:CHC(NO<sub>2<\/sub>)<sub>2<\/sub><sup>&#8211;<\/sup> K<sup>+<\/sup> in MeCN containing AcOH gave 17 and 18% nitropyrazoles <strong>II<\/strong> [R = Me, C(NO<sub>2<\/sub>)<sub>2<\/sub>], which underwent fluorination and chlorination to give 65 and 81% <strong>II<\/strong> [R = C(NO<sub>2<\/sub>)<sub>2<\/sub>F, C(NO<sub>2<\/sub>)<sub>2<\/sub>Cl]. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">SDS of cas: 5334-39-4<\/a>).<\/p>\n<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">SDS of cas: 5334-39-4<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">SDS of cas: 5334-39-4<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-12010","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Laikhter, A. L. et al. published their research in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1991 | CAS: 5334-39-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"gem-Dinitro compounds in organic synthesis. 2. Synthesis of 4-nitropyrazoles from dinitromethane and its derivatives was written by Laikhter, A. L.;Cherkasova, T. I.;Semenov, V. V.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1991.SDS of cas: 5334-39-4 This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=12010\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Laikhter, A. L. et al. published their research in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1991 | CAS: 5334-39-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"gem-Dinitro compounds in organic synthesis. 2. Synthesis of 4-nitropyrazoles from dinitromethane and its derivatives was written by Laikhter, A. L.;Cherkasova, T. I.;Semenov, V. V.. 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