{"id":11998,"date":"2023-01-05T03:44:33","date_gmt":"2023-01-04T19:44:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11998"},"modified":"2023-01-05T03:44:33","modified_gmt":"2023-01-04T19:44:33","slug":"zohdi-hussein-f-et-al-published-their-research-in-journal-of-chemical-research-synopses-in-1992-cas-401-73-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11998","title":{"rendered":"Zohdi, Hussein F. et al. published their research in Journal of Chemical Research, Synopses in 1992 | CAS: 401-73-0"},"content":{"rendered":"<p>Reactions with 5-trifluoromethyl-2,4-dihydropyrazol-3-one derivatives:  a new route for the synthesis of fluorinated polyfunctionally substituted pyrazole and pyrano[2,3-c]pyrazole derivatives was written by Zohdi, Hussein F.;Elghandour, Ahmed H. H.;Rateb, Nora M.;Sallam, Mohamed M. M.. And the article was included in Journal of Chemical Research, Synopses in 1992.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Safety of 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one<\/a> This article mentions the following:<\/p>\n<p>Reaction of trifluoromethylpyrazolones <strong>I<\/strong> (R = H, Ph) with R<sup>1<\/sup>CH:C(CN)<sub>2<\/sub> (R<sup>1<\/sup> = Ph, 4-MeC<sub>6<\/sub>H<sub>4<\/sub>, 4-MeOC<sub>6<\/sub>H<sub>4<\/sub>, 4-ClC<sub>6<\/sub>H<sub>4<\/sub>, 2-furyl) in the presence of piperidine gave pyranopyrazoles <strong>II<\/strong>. Cyclocondensation of <strong>I<\/strong> (R = Ph) with R<sup>1<\/sup>COCH<sub>2<\/sub>COR<sup>2<\/sup> (R<sup>1<\/sup> = Me, CF<sub>3<\/sub>; R<sup>2<\/sup> = OEt, NHPh) gave pyranopyrazoles <strong>III<\/strong> (R<sup>1<\/sup> = Me, CF<sub>3<\/sub>). <strong>I<\/strong> (R = Ph) reacted with dibenzoylmethane and acetylacetone to give derivatives <strong>IV<\/strong> and <strong>V<\/strong> resp. The reactions of <strong>I<\/strong> (R = Ph) with aromatic aldehydes are also reported. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Safety of 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one<\/a>).<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Safety of 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.<a href=\"https:\/\/www.ambeed.com\/products\/401-73-0.html\">Safety of 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11998","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Zohdi, Hussein F. et al. published their research in Journal of Chemical Research, Synopses in 1992 | CAS: 401-73-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Reactions with 5-trifluoromethyl-2,4-dihydropyrazol-3-one derivatives: a new route for the synthesis of fluorinated polyfunctionally substituted pyrazole and pyrano[2,3-c]pyrazole derivatives was written by Zohdi, Hussein F.;Elghandour, Ahmed H. H.;Rateb, Nora M.;Sallam, Mohamed M. M.. And the article was included in Journal of Chemical Research, Synopses in 1992.Safety of 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11998\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zohdi, Hussein F. et al. published their research in Journal of Chemical Research, Synopses in 1992 | CAS: 401-73-0 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Reactions with 5-trifluoromethyl-2,4-dihydropyrazol-3-one derivatives: a new route for the synthesis of fluorinated polyfunctionally substituted pyrazole and pyrano[2,3-c]pyrazole derivatives was written by Zohdi, Hussein F.;Elghandour, Ahmed H. 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