{"id":11997,"date":"2023-01-05T03:44:33","date_gmt":"2023-01-04T19:44:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11997"},"modified":"2023-01-05T03:44:33","modified_gmt":"2023-01-04T19:44:33","slug":"hemalatha-b-et-al-published-their-research-in-international-journal-of-pharmaceutical-sciences-review-and-research-in-2013-cas-5334-39-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11997","title":{"rendered":"Hemalatha, B. et al. published their research in International Journal of Pharmaceutical Sciences Review and Research in 2013 | CAS: 5334-39-4"},"content":{"rendered":"<p>Design, synthesis, characterization and pharmacological evaluation of antimycobacterial agents targeting dapb (dihydrodipicolinate reductase) was written by Hemalatha, B.;Shanthakumar, B.;Sekar, A. M.. And the article was included in International Journal of Pharmaceutical Sciences Review and Research in 2013.<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Product Details of 5334-39-4<\/a> This article mentions the following:<\/p>\n<p>Pyrazole, a heterocyclic nucleus were found to exhibit a wide range of biol. activities were selected to prepare a database which was then docked against dihydrodipicolinate reductase (dapB) using Glide software (Maestro version -9.1) for antitubercular activity. The compounds with top scores were selected, synthesized, characterized by IR, NMR and mass spectroscopy and screened for in-vitro antitubercular activity by microplate alamar blue assay. All compounds shows a significant antitubercular activity at the min. inhibitory concentration varied between 25\u03bcg\/mL and 100\u03bcg\/mL. Inhibition was compared using pyrazinamide 3.125\u03bcg\/mL and streptomycin 6.25\u03bcg\/mL as standard In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4<a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Product Details of 5334-39-4<\/a>).<\/p>\n<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Product Details of 5334-39-4<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/5334-39-4.html\">Product Details of 5334-39-4<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11997","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hemalatha, B. et al. published their research in International Journal of Pharmaceutical Sciences Review and Research in 2013 | CAS: 5334-39-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Design, synthesis, characterization and pharmacological evaluation of antimycobacterial agents targeting dapb (dihydrodipicolinate reductase) was written by Hemalatha, B.;Shanthakumar, B.;Sekar, A. 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