{"id":11993,"date":"2023-01-05T03:44:33","date_gmt":"2023-01-04T19:44:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11993"},"modified":"2023-01-05T03:44:33","modified_gmt":"2023-01-04T19:44:33","slug":"kost-a-n-et-al-published-their-research-in-zhurnal-obshchei-khimii-in-1963-cas-15953-73-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11993","title":{"rendered":"Kost, A. N. et al. published their research in Zhurnal Obshchei Khimii in 1963 | CAS: 15953-73-8"},"content":{"rendered":"<p>Pyrazoles. XXXVI. Chromatography of pyrazoles in unfixed thin layer of aluminum oxide was written by Kost, A. N.;Faizova, G. K.;Grandberg, I. I.. And the article was included in Zhurnal Obshchei Khimii in 1963.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">COA of Formula: C5H7ClN2<\/a> This article mentions the following:<\/p>\n<p>The R<sub>f<\/sub> values are tabulated for 48 substituted pyrazoles in thin layer Al<sub>2<\/sub>O<sub>3<\/sub> chromatography. Solvent system of petr. ether-CHCl<sub>3<\/sub> was satisfactory for separation of 1-alkylpyrazoles; pyrazoles without 1-substituent moved but little in this system, but gave good movement in systems such as C<sub>6<\/sub>H<sub>6<\/sub>-MeOH or C<sub>6<\/sub>H<sub>6<\/sub>-Me<sub>2<\/sub>CO. Mixtures of isomeric substituted pyrazoles were effectively separated by this procedure. Some difficulty was encountered in separation of 1-phenyl-3- and -4-halopyrazoles only. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">COA of Formula: C5H7ClN2<\/a>).<\/p>\n<p>4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">COA of Formula: C5H7ClN2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.  Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/15953-73-8.html\">COA of Formula: C5H7ClN2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11993","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kost, A. N. et al. published their research in Zhurnal Obshchei Khimii in 1963 | CAS: 15953-73-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazoles. XXXVI. 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