{"id":11990,"date":"2023-01-05T03:44:33","date_gmt":"2023-01-04T19:44:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11990"},"modified":"2023-01-05T03:44:33","modified_gmt":"2023-01-04T19:44:33","slug":"nagahara-katsuhiko-et-al-published-their-research-in-journal-of-heterocyclic-chemistry-in-1994-cas-18213-75-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11990","title":{"rendered":"Nagahara, Katsuhiko et al. published their research in Journal of Heterocyclic Chemistry in 1994 | CAS: 18213-75-7"},"content":{"rendered":"<p>Reaction of 5-aminopyrazole derivatives with ethoxymethylenemalononitrile and its analogs was written by Nagahara, Katsuhiko;Kawano, Hiroko;Sasaoka, Shinji;Ukawa, Chisa;Hirama, Tamaki;Takada, Atsushi;Cottam, Howard B.;Robins, Roland K.. And the article was included in Journal of Heterocyclic Chemistry in 1994.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Category: pyrazoles-derivatives<\/a> This article mentions the following:<\/p>\n<p>A one-pot synthesis using 5-aminopyrazole derivatives with ethoxymethylenemalonitrile (EMMN), Et ethoxymethylenecyanoacetate (EMCA) or di-Et ethoxymethylenemalonate (DEMM) gave pyrazolo[1,5-a]pyrimidine compounds Also, the one step reaction of EMCA with hydrazine hydrate afforded ethyl(4-ethoxycarbonyl-5-pyrazolyl)aminomethylenecyanoacetate. On the other hand, the reaction of 1-substituted 5-aminopyrazole-4-carboxamide with EMMN afforded pyrazolo[3,4-d]pyrimidine compounds In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Category: pyrazoles-derivatives<\/a>).<\/p>\n<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Category: pyrazoles-derivatives<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. <a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Category: pyrazoles-derivatives<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11990","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nagahara, Katsuhiko et al. published their research in Journal of Heterocyclic Chemistry in 1994 | CAS: 18213-75-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Reaction of 5-aminopyrazole derivatives with ethoxymethylenemalononitrile and its analogs was written by Nagahara, Katsuhiko;Kawano, Hiroko;Sasaoka, Shinji;Ukawa, Chisa;Hirama, Tamaki;Takada, Atsushi;Cottam, Howard B.;Robins, Roland K.. 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