{"id":11986,"date":"2023-01-05T03:44:33","date_gmt":"2023-01-04T19:44:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11986"},"modified":"2023-01-05T03:44:33","modified_gmt":"2023-01-04T19:44:33","slug":"kurihara-takushi-et-al-published-their-research-in-journal-of-heterocyclic-chemistry-in-1980-cas-18213-75-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11986","title":{"rendered":"Kurihara, Takushi et al. published their research in Journal of Heterocyclic Chemistry in 1980 | CAS: 18213-75-7"},"content":{"rendered":"<p>Reaction of 2-aminobenzamide analogs and 2-aminothiophenol with ethyl 3-ethoxymethylene-2,4-dioxovalerate.  Synthesis of pyrrolo[1,2-a]quinazoline and pyrrolo[1,2-a]benzothiazoline derivatives was written by Kurihara, Takushi;Tani, Tsutomu;Maeyama, Sigeru;Sakamoto, Yasuhiko. And the article was included in Journal of Heterocyclic Chemistry in 1980.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Computed Properties of C5H8N4O<\/a> This article mentions the following:<\/p>\n<p>The reaction of EtOCH:C(COMe)COCO<sub>2<\/sub>Et (<strong>I<\/strong>) with 2-H<sub>2<\/sub>NC<sub>6<\/sub>H<sub>4<\/sub>CXNHR (X = O, R = H, Me; X = S, R = H) and 3-amino-2-methyl- or phenylpyrazole-4-carboxamides produced Et 3-aminomethylene-2,4-dioxovalerates, which led to pyrrolo[1,2-<em>a<\/em>]quinazoline-1,5-diones (<strong>II<\/strong>) and pyrrolo[1,2-<em>a<\/em>]pyrazolo[4,3-<em>e<\/em>]pyrimidine-1,5-dione (<strong>III<\/strong>) under the acidic conditions. Analogously, 2-H<sub>2<\/sub>NC<sub>6<\/sub>H<sub>4<\/sub>SH reacted with <strong>I<\/strong> to give 2-HSC<sub>6<\/sub>H<sub>4<\/sub>NHCH:C(COMe)COCO<sub>2<\/sub>Et, which was converted to pyrrolo[1,2-<em>a<\/em>]benzothiazolin-1-one under the neutral conditions. Furthermore, the heterocyclic steroidal mols. <strong>IV<\/strong> and <strong>V<\/strong> (R<sup>1<\/sup> = H, Me, Ph) were prepared by condensation of <strong>II<\/strong> and <strong>III<\/strong> with R<sup>1<\/sup>NHNH<sub>2<\/sub>. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Computed Properties of C5H8N4O<\/a>).<\/p>\n<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Computed Properties of C5H8N4O<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.<a href=\"https:\/\/www.ambeed.com\/products\/18213-75-7.html\">Computed Properties of C5H8N4O<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[128],"class_list":["post-11986","post","type-post","status-publish","format-standard","hentry","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kurihara, Takushi et al. published their research in Journal of Heterocyclic Chemistry in 1980 | CAS: 18213-75-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Reaction of 2-aminobenzamide analogs and 2-aminothiophenol with ethyl 3-ethoxymethylene-2,4-dioxovalerate. Synthesis of pyrrolo[1,2-a]quinazoline and pyrrolo[1,2-a]benzothiazoline derivatives was written by Kurihara, Takushi;Tani, Tsutomu;Maeyama, Sigeru;Sakamoto, Yasuhiko. And the article was included in Journal of Heterocyclic Chemistry in 1980.Computed Properties of C5H8N4O This article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11986\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kurihara, Takushi et al. published their research in Journal of Heterocyclic Chemistry in 1980 | CAS: 18213-75-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Reaction of 2-aminobenzamide analogs and 2-aminothiophenol with ethyl 3-ethoxymethylene-2,4-dioxovalerate. Synthesis of pyrrolo[1,2-a]quinazoline and pyrrolo[1,2-a]benzothiazoline derivatives was written by Kurihara, Takushi;Tani, Tsutomu;Maeyama, Sigeru;Sakamoto, Yasuhiko. 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Synthesis of pyrrolo[1,2-a]quinazoline and pyrrolo[1,2-a]benzothiazoline derivatives was written by Kurihara, Takushi;Tani, Tsutomu;Maeyama, Sigeru;Sakamoto, Yasuhiko. 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